Catalog Number - 68524-P50-250

Cogent RP Phenyl™ Process HPLC Columns are designed for high-capacity purification, process development, and production-scale chromatography involving aromatic compounds and structurally related analytes. Manufactured using ultra-high purity silica bonded with a three-carbon linker and terminal Phenyl functionality, this stationary phase is fully double end-capped to minimize secondary interactions and provide highly reproducible chromatographic performance. RP Phenyl™ offers enhanced aromatic selectivity and is an excellent choice for process-scale separations involving compounds containing phenyl rings and related structures.

68524-P50-250 is packed with 5 µm RP Phenyl™ particles featuring a 100Å pore size in a 50 mm ID x 250 mm process-scale format. The 5 µm particle size performs well at elevated process flow rates while maintaining moderate operating backpressure. The large internal diameter and extended column length provide very high sample loading capacity and maximum chromatographic resolution, making this column ideal for process development, production purification, and manufacturing-scale chromatographic applications.

The 50 mm ID x 250 mm format is particularly well suited for purification of positional isomers, tocopherols, flavonoids, polynuclear aromatic hydrocarbons, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, and related compounds containing aromatic structures. Typical operating flow rates are approximately 80–140 mL/min depending on mobile phase composition, system pressure limitations, and application requirements. A process-scale HPLC system capable of supporting these flow rates and sample loads is required.

Key Benefits

• RP Phenyl™ stationary phase

• USP L11 equivalent chemistry

• Ultra-high purity silica support

• Fully double end-capped

• Phenyl bonded phase

• 100Å pore size

• Suitable for reversed-phase chromatography

• Enhanced aromatic selectivity

• Very high sample loading capacity

• Ideal for process-scale purification

Typical Applications

• Process HPLC

• Production-scale purification

• Positional isomer separations

• Tocopherol purification

• Flavonoid purification

• Polynuclear aromatic hydrocarbon separations

• Nitro-aromatic compound purification

• Active pharmaceutical ingredient (API) purification

• Natural product isolation

• Process development and scale-up

Specifications

• Product Type: Process HPLC Column

• Stationary Phase: RP Phenyl™

• Chromatography Mode: Reversed Phase

• USP Classification: L11

• Particle Size: 5 µm

• Pore Size: 100Å

• Column Dimensions: 50 mm ID x 250 mm

• Recommended Flow Rate: 80–140 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Suitable for reversed-phase chromatography

• USP L11 equivalent chemistry

• Fully double end-capped stationary phase

• Excellent selectivity for aromatic compounds

• Ideal for purification of compounds containing phenyl ring structures

• Very high loading capacity for process-scale applications

• Typical operating range is approximately 80–140 mL/min

• Requires a specialized process HPLC system

• Well suited for process development, scale-up, and production chromatography

• This is a Special Order Item