Catalog Number - 72330-PG2

The 72330‑PG2 Cogent C30™ Guard Column Cartridges are designed to protect analytical C30 columns from particulates, strongly retained compounds, and matrix contamination, helping maintain consistent performance and extend column life.

Packed with 3 µm C30 stationary phase, these cartridges use a 30‑carbon bonded ligand on high‑purity silica (non‑end capped) to ensure matching selectivity with your analytical column. This preserves method integrity, especially for shape‑selective separations of hydrophobic isomers.

The 200 Å pore size supports applications involving larger molecules, including carotenoids, vitamins, peptides, and similar compounds where selectivity and reproducibility are critical.

✅ Comparable selectivity to YMC® C30 columns, ensuring compatibility with equivalent analytical methods and workflows

Guard Function – Protecting Analytical Performance

These guard cartridges act as a sacrificial protection layer, capturing contaminants before they reach the analytical column.

• Traps particulates and sample debris

• Reduces adsorption of strongly retained compounds

• Maintains retention time stability and peak shape

✅ Helps extend column life and method reproducibility

Designed for Analytical Columns (3.0–4.6 mm ID)

Compatible with:

• 3.0 mm ID solvent‑saving columns

• 4.0 mm ID analytical columns

• 4.6 mm ID standard HPLC columns

Maintains matching C30 chemistry and selectivity, ensuring no disruption to chromatographic performance.

Flow Rate & System Considerations (4.0 mm, 3 µm)

⚠️ Compatible with standard analytical HPLC systems

• Typical flow rate range: ~0.8–1.5 mL/min

• Minimal added system volume

• Maintains column efficiency and resolution

• Monitor system pressure due to 3 µm particle size

✅ Install upstream of the analytical column for optimal protection

Why Use C30 Guard Cartridges

Preserve Shape Selectivity

• Same C30 phase as analytical column

• Maintains separation of positional and geometric isomers

Extend Column Lifetime

• Reduces fouling and contamination

• Minimizes analytical column replacement

Improve Workflow Reliability

• Maintains consistent retention and peak shape

• Supports reproducible results across runs

Cogent C30™ Guard Advantages

Matched C30 Chemistry

• Equivalent selectivity to analytical columns

• Comparable to YMC® C30 column workflows

High‑Efficiency 3 µm Media

• Maintains chromatographic performance

• Minimal impact on resolution

Durable Construction

• Stainless steel cartridge body

• Stainless steel frits with PEEK caps

Typical Applications

• Carotenoid and vitamin analysis

• Isomer and positional separations

• Peptide and large molecule workflows

• Hydrophobic compound profiling

• Analytical method protection

Important Usage Notes

• ⚠️ Requires a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID)

• Replace regularly to maintain optimal protection and performance