HPLC Column, HPS C18, 5um, 4.6mm ID x 100mm Length, 120A. Cogent Brand. 1 EA.
Additional Info:
The 75018‑10P Cogent HPS C18™ HPLC Column is engineered for reliable, high‑purity reversed‑phase chromatography, delivering excellent peak shape, reproducibility, and consistent selectivity.
Built with monofunctional C18 bonding on proprietary high‑purity silica with full end‑capping, this column minimizes unwanted interactions while ensuring robust performance for both USP L1 methods and new method development.
✅ Frequently used as a cost‑effective alternative to Inertsil™ C18 and Luna™ C18 columns
100 mm Length – Increased Resolution for Analytical Methods
Higher resolving power than 50 mm columns
Improves separation of closely eluting compounds
Increases peak capacity for complex samples
Ideal for method development and refinement workflows
✅ Selected when greater resolution is required beyond fast screening methods
4.6 mm ID – Standard Analytical Platform
Compatible with standard HPLC systems
Ideal for:
routine QC analysis
method validation and transfer
Typical Flow Rate Range
~0.8–1.5 mL/min
✅ Provides robust, reproducible analytical performance
5 µm Particle – Proven Performance & Low Backpressure
Provides:
Reliable efficiency for analytical methods
Lower backpressure vs smaller particle sizes
Long column lifetime
✅ Ideal for:
Routine laboratory workflows
Method transfer across systems and labs
120 Å Pore Size – Enhanced Versatility
Larger than traditional 100 Å pores
Improves interaction with:
moderately larger molecules
complex compound structures
✅ Provides balanced retention and selectivity across diverse analytes
Why Choose HPS C18™ Columns
High‑Purity Silica Platform
Reduces:
metal contamination
secondary interactions
Improves:
peak symmetry
analytical reproducibility
Monofunctional C18 Bonding
Provides:
controlled and predictable surface chemistry
enhanced method consistency
✅ Ideal for method development and validation workflows
Cost‑Performance Advantage
Comparable to:
Inertsil™ C18
Luna™ C18
✅ Delivers premium performance at a competitive cost
Application Performance Advantages
Suitable for:
Hydrophobic compounds
Neutral analytes
Long‑chain fatty acids
Provides:
Longer retention compared to C8 columns
Reliable separation across routine and complex analyses
✅ Ideal for general‑purpose reversed‑phase HPLC workflows
System & Sample Considerations
Compatible with standard HPLC systems
Suitable for routine and analytical workflows
Recommended sample preparation:
👉 Use 0.2 µm syringe filters for proper sample preparation before injection
✅ Helps:
Prevent column fouling
Maintain long‑term analytical performance
Typical Applications
USP L1 analytical methods
Pharmaceutical QC and validation
Routine HPLC analysis
Method development and transfer
Hydrophobic compound separations
Long‑chain fatty acid analysis
Important Usage Notes
Designed for standard analytical HPLC systems (4.6 mm ID)
Suitable for USP L1 methods and new method development
Ideal for resolution‑focused analytical workflows
Monitor system pressure relative to instrument specifications