Catalog Number - 75018-10P-2

The 75018‑10P‑2 Cogent HPS C18™ HPLC Column is engineered for high‑purity, low‑flow chromatographic performance, delivering consistent retention, excellent peak shape, and reproducible selectivity.

Built with monofunctional C18 bonding on proprietary high‑purity silica with full double end‑capping, this column minimizes secondary interactions and provides clean baselines for sensitive LC‑MS applications.

✅ Frequently used as a cost‑effective alternative to Inertsil™ C18 and Luna™ C18 columns

100 mm Length – Increased Resolution for LC‑MS Methods

• Higher resolving power than 50 mm columns

• Improves separation of closely eluting analytes

• Increases peak capacity for complex mixtures

• Ideal for method refinement after initial screening

✅ Selected when greater resolution is needed in LC‑MS workflows

2.1 mm ID – LC‑MS / Low‑Flow Optimization

• Designed for low‑flow HPLC and LC‑MS systems

• Enhances mass spectrometry sensitivity via reduced solvent flow

Typical Flow Rate Range

• ~0.2–0.3 mL/min

✅ Requires systems capable of stable, precise low‑flow delivery

⚠️ Ensure:

• Accurate pump control

• Compatibility with low‑volume detector flow cells

5 µm Particle – Balanced Efficiency & System Compatibility

• Provides:

  • Reliable efficiency for routine LC‑MS methods

  • Lower backpressure vs smaller particles

  • Long column lifetime

✅ Ideal for:

• LC‑MS systems without UHPLC pressure capacity

• Method transfer and reproducibility

120 Å Pore Size – Enhanced Analytical Versatility

• Slightly larger pore size vs 100 Å phases

• Improves performance with:

  • moderately larger molecules

  • complex analytes

✅ Provides balanced retention and selectivity across diverse sample types

Why Choose HPS C18™ Columns

High‑Purity Silica Platform

• Reduces:

  • metal impurities

  • secondary interactions

• Improves:

  • peak symmetry

  • analytical reproducibility

Monofunctional C18 Bonding

• Provides:

  • predictable surface chemistry

  • consistent method performance

✅ Ideal for method development and validation workflows

LC‑MS Performance Advantage

• Low bleed and clean baseline

• Compatible with high‑sensitivity MS detection

✅ Preferred for trace‑level LC‑MS analysis

Cost‑Performance Alternative

• Comparable performance to:

  • Inertsil™ C18

  • Luna™ C18

✅ Delivers premium‑level performance at competitive pricing

Application Performance Advantages

• Suitable for:

  • Hydrophobic compounds

  • Neutral analytes

  • Long‑chain fatty acids

• Provides:

  • Strong retention vs C8 phases

  • High reproducibility in LC‑MS workflows

✅ Ideal for general‑purpose LC‑MS and HPLC analytical methods

System & Sample Considerations

• Designed for low‑flow LC‑MS systems (2.1 mm ID)

• Requires precise pump control and optimized detector configuration

Recommended sample preparation:

• 👉 Use 0.2 µm syringe filters for proper LC‑MS sample preparation before injection

✅ Helps:

• Prevent column clogging

• Maintain long‑term analytical performance

Typical Applications

• LC‑MS and LC‑MS/MS workflows

• USP L1 analytical methods

• Pharmaceutical QC and validation

• Method development and optimization

• Hydrophobic compound separations

• Trace‑level analytical workflows

Important Usage Notes

• Designed for low‑flow LC‑MS systems (~0.2–0.3 mL/min)

• Requires stable and precise pump performance

• Ideal for resolution‑focused LC‑MS workflows

• Monitor pressure relative to instrument capability