Catalog Number - 75018-15P

The 75018‑15P Cogent HPS C18™ HPLC Column is engineered for reliable, high‑resolution reversed‑phase chromatography, offering excellent peak shape, reproducibility, and selectivity for demanding analytical workflows.

Featuring monofunctional C18 bonding on proprietary high‑purity silica with full double end‑capping, this column minimizes secondary interactions and provides stable chromatographic performance for USP L1 methods and new method development.

✅ One of the most popular HPS™ C18 columns for routine and advanced analytical use

✅ Frequently used as a cost‑effective alternative to Inertsil™ C18 and Luna™ C18 columns

150 mm Length – High Resolution for Analytical Methods

• Provides greater resolving power than shorter columns

• Improves separation of closely related analytes

• Increases peak capacity for complex mixtures

• Ideal for method development, validation, and refinement

✅ Selected when resolution and reproducibility are critical

4.6 mm ID – Standard Analytical Platform

• Compatible with standard HPLC systems

• Ideal for:

  • routine QC analysis

  • method validation and transfer

Typical Flow Rate Range

• ~0.8–1.5 mL/min

✅ Delivers robust and reproducible analytical performance

5 µm Particle – Proven Performance & Reliability

• Provides:

  • Consistent efficiency for analytical separations

  • Lower backpressure vs smaller particles

  • Extended column lifetime

✅ Ideal for:

• Routine and regulated workflows

• Method transfer across laboratories

120 Å Pore Size – Enhanced Selectivity & Versatility

• Larger pore size compared to standard 100 Å phases

• Improves performance for:

  • moderately larger molecules

  • complex analytes

✅ Provides balanced retention and expanded method flexibility

Why Choose HPS C18™ Columns

High‑Purity Silica Platform

• Reduces:

  • metal impurities

  • secondary interactions

• Improves:

  • peak symmetry

  • analytical reproducibility

Monofunctional Bonding Technology

• Provides:

  • controlled and predictable surface chemistry

  • consistent retention behavior

✅ Ideal for validated and reproducible methods

Cost‑Performance Advantage

• Comparable performance to:

  • Inertsil™ C18

  • Luna™ C18

✅ Delivers premium performance at a competitive price point

Application Performance Advantages

• Suitable for:

  • Hydrophobic compounds

  • Neutral analytes

  • Long‑chain fatty acids

• Provides:

  • Stronger retention vs C8 phases

  • Consistent separation across routine and complex analyses

✅ Ideal for general‑purpose reversed‑phase chromatography

System & Sample Considerations

• Compatible with standard HPLC systems

• Suitable for routine and high‑throughput workflows

Recommended sample preparation:

• 👉 Use 0.2 µm syringe filters for proper sample preparation before injection

✅ Helps:

• Prevent column fouling

• Maintain long‑term analytical performance

Typical Applications

• USP L1 analytical methods

• Pharmaceutical QC and validation

• Method development and optimization

• Hydrophobic compound separations

• Long‑chain fatty acid analysis

• Routine HPLC workflows

Important Usage Notes

• Designed for standard analytical HPLC systems (4.6 mm ID)

• Suitable for USP L1 methods and new method development

• Ideal for high‑resolution analytical workflows

• Monitor system pressure relative to instrument specifications