Prep HPLC Column, HPS C18, 5um, 120A. 21.2mm ID x 150mm Length. Cogent Brand. 1 EA.
Additional Info:
The 75018‑P150 Cogent HPS C18™ Preparative Column is designed for high‑resolution purification and advanced method scaling, delivering strong retention, excellent peak symmetry, and consistent chromatographic performance.
Manufactured using high‑purity silica with monofunctional C18 bonding and full double end‑capping, this stationary phase minimizes secondary interactions and provides reliable results when scaling methods from analytical and semi‑preparative columns into full preparative workflows.
This column is particularly effective for purification of hydrophobic and neutral compounds, including long‑chain fatty acids, where resolution and fraction purity are critical.
150 mm Length – High Resolution for Preparative Purification
The 150 mm length provides greater resolving power than 50 mm and 100 mm columns, allowing more complete separation of closely related compounds before collection.
Improved separation of difficult mixtures
Higher fraction purity and recovery
Increased peak capacity for complex samples
✅ Use when 100 mm columns do not provide sufficient resolution, but full 250 mm length is not required
Flow Rate & System Requirements (21.2 mm ID, 5 µm)
⚠️ Requires a preparative HPLC system capable of high flow rates and large sample loading
Typical flow rate range: ~15–40 mL/min
High injection volume capability required
Preparative detector flow cell recommended
Stable high‑flow pump performance critical
✅ Sample preparation requirement: use appropriate filtration (0.2 µm or 0.45 µm) to prevent clogging and maintain column performance
Why Choose HPS C18 for Preparative Work
High‑Resolution Purification
Enables separation of closely eluting compounds prior to collection
Improves final product purity
Scalable Method Transfer
Maintains selectivity across 4.6 mm → 10 mm → 21.2 mm formats
Eliminates need for method redevelopment during scale‑up
High‑Purity Silica Platform
Reduces variability and secondary interactions
Improves reproducibility and fraction consistency
Cogent HPS C18™ Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry, especially for challenging analytes
Monofunctional Bonding
Predictable and consistent selectivity
Stable retention across workflows
Preparative Durability
Lower backpressure vs smaller particle sizes
Designed for repeated high‑load injections
Typical Applications
Preparative purification
Method scaling and process development
Hydrophobic and neutral compound isolation
Fraction collection and compound recovery
Pharmaceutical and chemical purification workflows
Important Usage Notes
Requires preparative HPLC system (21.2 mm ID compatibility)
Not suitable for standard analytical systems
Designed for high‑flow, high‑load purification workflows
👉 Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable