Prep HPLC Column, HPS C18, 5um, 120A. 21.2mm ID x 250mm Length. Cogent Brand. 1 EA.
Additional Info:
The 75018‑P250 Cogent HPS C18™ Preparative Column is designed for maximum‑resolution purification and production‑scale separations, delivering strong retention, excellent peak symmetry, and highly reproducible results.
Manufactured with high‑purity silica, monofunctional C18 bonding, and full double end‑capping, this stationary phase minimizes secondary interactions and ensures consistent chromatographic performance during full scale‑up from analytical and semi‑preparative methods.
This column is particularly effective for purification of hydrophobic and neutral compounds, including long‑chain fatty acids, where the highest level of separation and compound purity is required.
250 mm Length – Maximum Resolution & Purification Power
The 250 mm length provides the highest resolving power in the preparative HPS range, enabling separation of closely related impurities and trace components.
Maximum separation for complex mixtures
Highest peak capacity for difficult samples
Superior fraction purity and isolation accuracy
✅ Use when 150 mm columns do not achieve required purity or separation performance
Flow Rate & System Requirements (21.2 mm ID, 5 µm)
⚠️ Requires a preparative HPLC system designed for high flow rates and large sample loading
Typical flow rate range: ~15–40 mL/min
High injection volumes required for production work
Preparative detector flow cell recommended
System must deliver stable, high‑flow performance
✅ Sample preparation requirement: use appropriate filtration (0.2 µm or 0.45 µm) to prevent clogging and protect column lifetime
Why Choose HPS C18 for Preparative Work
Maximum Resolution for Production Workflows
Enables purification of closely related compounds and impurities
Ideal for demanding purification applications
Seamless Method Scaling
Maintains selectivity across 4.6 mm → 10 mm → 21.2 mm columns
Eliminates need for redevelopment during scale‑up
High‑Purity Silica Platform
Reduces variability and secondary interactions
Improves reproducibility and fraction consistency
Cogent HPS C18™ Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak shape for difficult analytes
Monofunctional Bonding
Predictable, stable selectivity
Consistent chromatographic behavior across workflows
Preparative Durability
Lower backpressure than smaller particles
Designed for repeated, high‑load purification cycles
Typical Applications
Preparative purification at scale
Process and production chromatography
Hydrophobic and neutral compound isolation
Impurity profiling and fraction collection
Pharmaceutical and chemical manufacturing workflows
Important Usage Notes
Requires preparative HPLC system (21.2 mm ID compatibility)
Not suitable for standard analytical systems
Designed for high‑flow, production‑scale purification workflows
👉 Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable