HPLC Column, HPS Cyano, 5um, 2.1mm ID x 100mm Length, 120A. Cogent Brand. 1 EA.
Additional Information:
Cogent HPS Cyano™ HPLC Columns are designed for versatile reversed-phase separations of polar and neutral compounds requiring moderate retention, rapid equilibration, and reproducible chromatographic performance. Manufactured using a monofunctional three-carbon ligand with a terminal cyano functional group bonded to high-purity 120Å silica and fully end capped, this stationary phase offers unique selectivity characteristics that are widely used as an alternative for USP L10 methods and for new method development. The HPS product line was developed to provide a high-value option for laboratories seeking performance characteristics comparable to established cyano phases from leading manufacturers.
75025-10P-2 is packed with 5 µm HPS Cyano™ particles in a 2.1 mm ID x 100 mm analytical format. The 5 µm particle size provides reliable chromatographic efficiency with lower operating backpressure than smaller particles, while the 100 mm column length provides enhanced resolving power compared to shorter formats. The narrow-bore design reduces solvent consumption and is especially valuable for LC-MS applications where improved sensitivity and reduced mobile phase flow are beneficial.
The HPS Cyano™ stationary phase is commonly used for polar and neutral compounds analyzed using reversed-phase chromatography. Compared to non-modified silica columns, the cyano phase provides faster equiliation between runs and shorter retention times while maintaining excellent selectivity. This column is frequently selected for LC-MS methods, pharmaceutical analysis, method development, and analytical workflows requiring efficient separations with moderate retention characteristics.
Key Benefits
HPS Cyano™ stationary phase
USP L10 equivalent chemistry
Fully end capped
Monofunctional cyano bonded phase
High-purity 120Å silica
5 µm particle size
Lower operating backpressure
Faster equilibration between runs
Shorter retention than non-modified silica
Excellent for LC-MS applications
Typical Applications
USP L10 methods
LC-MS and LC-MS/MS methods
Reversed-phase HPLC
Polar compound analysis
Neutral compound analysis
Pharmaceutical analysis
Method development
Method validation
Routine quality control
Preparative method scouting
Specifications
Product Type: Analytical HPLC Column
Stationary Phase: HPS Cyano™
USP Classification: L10
Chromatography Mode: Reversed Phase
Particle Size: 5 µm
Pore Size: 120Å
Column Dimensions: 2.1 mm ID x 100 mm
Recommended Flow Rate: 0.2–0.3 mL/min
Column Hardware: Stainless Steel
Brand: Cogent
Important Notes
Suitable for reversed-phase chromatography
USP L10 equivalent chemistry
Fully end capped stationary phase
Designed for polar and neutral compounds
Provides faster equilibration than non-modified silica columns
Delivers shorter retention times than silica phases
Well suited for LC-MS applications
2.1 mm ID columns require an HPLC system capable of reliable low-flow operation
Low-volume detector flow cells are recommended for optimal performance
Frequently compared with established cyano columns from Inertsil™ and Luna™ product families
100 mm length provides an excellent balance of speed and chromatographic resolution