Catalog Number - 82061-15P

Cogent NP Silica™ HPLC Columns are manufactured using ultra-high purity, low metal content, 100Å silica that remains completely unmodified, providing the native silica selectivity required for Normal Phase and HILIC chromatography. This popular stationary phase is widely used as an alternative for methods requiring USP L3 equivalent chemistry and is well suited for the retention and separation of hydrophilic and polar compounds that may be difficult to retain using reversed-phase methods.

82061-15P is packed with 10 µm NP Silica™ particles in a 4.6 mm ID x 150 mm analytical format. The larger 10 µm particle size produces substantially lower operating backpressure than smaller particle columns, allowing higher flow rates while maintaining reliable chromatographic performance. The 150 mm length provides increased retention and resolution compared to shorter columns, making it an excellent choice for method development and routine analytical applications where enhanced separation is required.

The unmodified silica surface delivers strong polar retention mechanisms in both HILIC and Normal Phase modes. The 4.6 mm ID format is the industry-standard analytical column dimension and is compatible with conventional HPLC systems. This column is frequently selected for analytical methods requiring additional resolving power while maintaining reasonable analysis times and lower system pressure.

Key Benefits

• NP Silica™ stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 100Å pore size

• 10 µm particle size

• Lower operating backpressure

• Higher flow rate capability

• Suitable for HILIC and Normal Phase chromatography

Typical Applications

• Hydrophilic compound analysis

• Polar compound separations

• HILIC chromatography

• Normal Phase chromatography

• USP L3 method replacement

• Pharmaceutical analysis

• Method development

• Quality control testing

• Research and development

• Routine analytical HPLC

Specifications

• Product Type: Analytical HPLC Column

• Stationary Phase: NP Silica™

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 10 µm

• Pore Size: 100Å

• Column Dimensions: 4.6 mm ID x 150 mm

• Recommended Flow Rate: 1.0–3.0 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• Designed for hydrophilic and polar compound separations

• Lower operating pressure than 3 µm and 5 µm particle columns

• Supports higher flow rates than smaller particle columns

• Compatible with standard analytical HPLC systems

• 150 mm length provides greater retention and resolution than shorter column formats

• Excellent for method development and routine analytical testing

• Frequently used as an alternative in methods specifying USP L3 chemistry