Catalog Number - 82061-P21-50

Cogent NP Silica™ Preparative HPLC Columns are trusted by leading laboratories worldwide for compound purification, method scale-up, and process chromatography applications. Manufactured from ultra-high purity, low metal content, 100Å silica that remains completely unmodified, this stationary phase provides the native silica selectivity required for the purification of lipids, hydrophilic compounds, polar analytes, and other challenging sample types. Suitable for both HILIC and Normal Phase chromatography, this stationary phase is equivalent to USP L3 silica chemistry and has been successfully used for many years in pharmaceutical, cannabis, chemical, and forensic laboratories around the world.

82061-P21-50 is packed with 10 µm NP Silica™ particles in a 21.2 mm ID x 50 mm preparative column format. The larger particle size allows operation at higher flow rates while producing substantially lower backpressure than smaller particle columns. The 21.2 mm internal diameter provides high sample loading capacity, while the 50 mm column length minimizes run times and solvent consumption, making it ideal for fast preparative separations, purification scouting, and high-throughput purification workflows.

The 10 µm particle design has made this column a proven choice for preparative HPLC, purification method development, and process-scale separations worldwide. Because the stationary phase chemistry remains consistent across analytical, preparative, and purification formats, methods developed on analytical NP Silica™ columns can often be scaled directly to larger ID columns with predictable chromatographic behavior. This makes the column especially valuable for rapid purification development, compound isolation, production purification, and process scale-up activities.

Key Benefits

• NP Silica™ stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 100Å pore size

• 10 µm particle size

• Lower operating backpressure

• High sample loading capacity

• Proven for preparative HPLC and purification

Typical Applications

• Preparative HPLC

• Compound purification

• Lipid purification

• Polar compound separations

• Hydrophilic compound purification

• HILIC chromatography

• Normal Phase chromatography

• Pharmaceutical purification

• Cannabis purification

• Forensic laboratory applications

Specifications

• Product Type: Preparative HPLC Column

• Stationary Phase: NP Silica™

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 10 µm

• Pore Size: 100Å

• Column Dimensions: 21.2 mm ID x 50 mm

• Recommended Flow Rate: 15–40 mL/min

• Sample Loading Capacity: Preparative Scale

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• Designed for purification of hydrophilic, polar, and charged compounds

• Lower operating pressure than smaller particle preparative columns

• High loading capacity for compound isolation and purification

• Frequently used in pharmaceutical, cannabis, chemical, and forensic laboratories worldwide

• Proven preparative HPLC technology used globally for many years

• Directly scalable from analytical NP Silica™ column methods

• Excellent for purification method development, process scale-up, and production chromatography

• Requires a preparative HPLC system capable of supporting flow rates of approximately 15–40 mL/min and larger column dimensions

• 50 mm length is ideal for rapid preparative separations, purification scouting, and high-throughput workflows

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.