Catalog Number - 82061-SP-PG1-3

Cogent NP Silica™ Wide Pore Semi-Preparative Guard Column Cartridges are designed to protect valuable semi-preparative HPLC columns from particulate matter, strongly retained contaminants, and sample matrix components that can shorten column life and reduce chromatographic performance. Packed with ultra-high purity, low metal content, 300Å NP Silica™ Wide Pore that remains completely unmodified, these guard cartridges provide the same chromatographic selectivity as the semi-preparative column they protect while helping maintain purification efficiency, recovery, and method reproducibility.

82061-SP-PG1-3 is packed with 10 µm NP Silica™ Wide Pore particles in a 10 mm ID x 10 mm semi-preparative guard cartridge format. The 300Å pore structure provides improved accessibility for proteins, peptides, biomolecules, and other large molecular weight compounds. Housed in stainless steel hardware with stainless steel frits, these cartridges are installed ahead of the analytical flow path to trap particulates and strongly retained contaminants before they reach the primary column bed.

For many years, Cogent NP Silica™ Wide Pore semi-preparative columns and guard cartridges have been trusted by pharmaceutical, biotechnology, cannabis, chemical, and forensic laboratories worldwide. Regular guard cartridge replacement can significantly extend column lifetime, reduce downtime, and lower operating costs while maintaining optimal chromatographic performance for demanding purification workflows.

Key Benefits

• NP Silica™ Wide Pore stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 300Å wide pore design

• 10 µm particle size

• Protects semi-preparative columns from contamination

• Helps extend column life

• Maintains chromatographic performance

Typical Applications

• Semi-preparative HPLC

• Protein purification

• Peptide purification

• Biomolecule isolation

• Large molecule separations

• HILIC chromatography

• Normal Phase chromatography

• Pharmaceutical purification

• Method development

• Column protection

Specifications

• Product Type: Semi-Preparative Guard Column Cartridge

• Stationary Phase: NP Silica™ Wide Pore

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 10 µm

• Pore Size: 300Å

• Cartridge Dimensions: 10 mm ID x 10 mm

• Hardware Material: Stainless Steel

• Frit Material: Stainless Steel

• Pack Size: 5/PK

• Brand: Cogent

Guard Column Holder Required

• Requires the Cogent 10 mm ID Semi-Preparative Guard Column Holder (83000-SP-GH) for installation and operation.

Important Notes

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• 300Å wide pore structure provides improved accessibility for proteins, peptides, and other large molecules

• Designed to protect NP Silica™ Wide Pore semi-preparative columns from particulates and strongly retained contaminants

• Helps extend semi-preparative column service life

• Maintains chromatographic performance and reproducibility

• Recommended for purification and semi-preparative workflows

• Compatible with Cogent 10 mm ID NP Silica™ Wide Pore semi-preparative columns

• Requires the Cogent 10 mm ID Semi-Preparative Guard Column Holder (83000-SP-GH)

• Packaged as 5 guard cartridges per package

• Requires a semi-preparative HPLC system capable of supporting higher flow rates

• Special Order Item Information

  • Please review the Special Order Item Information for complete details.

  • For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

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