Catalog Number - 82161-05P

Cogent NP Silica™ UHPLC Columns are designed for high-efficiency analytical separations using modern UHPLC and UPLC-type systems. Manufactured from ultra-high purity, low metal content, 100Å silica that remains completely unmodified, this stationary phase provides the native silica selectivity required for HILIC and Normal Phase chromatography. Equivalent to USP L3 silica chemistry, it is an excellent choice for developing new UHPLC methods and for transferring or optimizing established USP methods that specify L3 stationary phases.

82161-05P is packed with 1.8 µm NP Silica™ particles in a 4.6 mm ID x 50 mm analytical UHPLC column format. The small particle size produces exceptionally high efficiency, narrow peak widths, and increased peak capacity compared to larger particle columns. The 50 mm length is optimized for rapid separations and high-throughput analytical workflows, helping laboratories reduce run times while maintaining excellent chromatographic performance.

This column is ideal for the analysis of hydrophilic and polar compounds when increased efficiency, faster methods, or improved resolution are desired. The combination of ultra-high purity silica and 1.8 µm particle technology makes it well suited for pharmaceutical analysis, quality control testing, research laboratories, and advanced method development. Reduced solvent consumption and faster cycle times can help lower operating costs while increasing laboratory productivity.

Key Benefits

• NP Silica™ stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 100Å pore size

• 1.8 µm particle size

• High efficiency separations

• Increased peak capacity

• Reduced analysis times

Typical Applications

• UHPLC analysis

• UPLC-type systems

• HILIC chromatography

• Normal Phase chromatography

• USP L3 applications

• Pharmaceutical analysis

• Quality control testing

• Method development

• Research laboratories

• High-throughput analysis

Specifications

• Product Type: UHPLC Column

• Stationary Phase: NP Silica™

• USP Classification: L3

• Chromatography Modes: HILIC and Normal Phase

• Particle Size: 1.8 µm

• Pore Size: 100Å

• Column Dimensions: 4.6 mm ID x 50 mm

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Designed exclusively for UHPLC and UPLC-type systems

• UPLC is a trademarked brand designation of Waters Corporation

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent stationary phase

• Unmodified silica surface chemistry

• Manufactured from ultra-high purity, low metal content silica

• Provides significantly higher efficiency than larger particle columns

• Ideal for reducing run times while maintaining or improving resolution

• Excellent for method development and method optimization

• Reduced solvent consumption and increased sample throughput

• Requires a UHPLC system capable of operating at the elevated pressures generated by 1.8 µm particles

• Samples should be filtered using a 0.2 µm syringe filter prior to injection

• 50 mm length is optimized for rapid analysis and high-throughput workflows

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