Catalog Number - 84018-05P

The 84018‑05P Cogent RP C18 PE™ HPLC Column is designed for high‑throughput analytical method development and preparative scouting, utilizing 10 µm particles combined with a polar embedded amide group within a C18 ligand to deliver stable polar retention and rugged chromatographic performance.

Manufactured using high‑purity silica with fully double end‑capped bonding, this stationary phase provides:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Stable performance under high aqueous mobile phases, including 100% water

The embedded amide functionality enhances retention of polar compounds while preventing phase collapse typical of conventional C18 columns, maintaining strong hydrophobic selectivity for non‑polar analytes.

50 mm Length – Fast Scouting & Method Development

• Designed for rapid separations and short run times

• Ideal for method screening and development workflows

• Minimizes solvent use and analysis time

• Frequently used for preparative and scale‑up method scouting

4.6 mm ID – Standard Analytical Platform

• Compatible with standard HPLC systems

• Ideal for:

  • method development

  • routine analysis

  • scale‑up method transfer

Typical Flow Rate Range

• ~0.8–1.5 mL/min

✅ Suitable for standard analytical systems without special flow requirements

10 µm Particle – Preparative Scouting & High‑Flow Compatibility

• Designed for high flow rates and improved robustness

• Supports scaled method development toward preparative workflows

• Provides lower resistance to flow compared to smaller particles

✅ Ideal for method development where scalability and durability are prioritized

Why Choose RP C18 PE™ (Polar Embedded)

Enhanced Polar Retention

• Retains polar compounds without phase collapse

• Stable in 100% aqueous mobile phases

• Improves retention compared to standard C18 columns

Dual‑Mode Flexibility

• Functions in:

  • Reversed Phase (RP)

  • HILIC‑like behavior under appropriate conditions

Ideal for Method Development & Scale‑Up

• Suitable for:

  • polar analytes poorly retained on standard C18

  • method transfer from analytical to preparative scale

• Enables robust and scalable method development workflows

USP Method Compatibility

• Suitable as a USP L1 alternate

• Ideal for methods requiring:

  • high aqueous mobile phases

  • robust polar compound retention

Typical Applications

• Analytical method development

• Preparative method scouting and scale‑up

• Polar and hydrophilic compound separations

• Pharmaceutical QC and process development

• Long‑chain fatty acids

• Mixed polarity sample analysis

Cogent RP C18 PE™ Advantages

Polar Embedded Ligand

• Enhances interaction with polar analytes

• Maintains traditional C18 hydrophobic selectivity

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry and reproducibility

High Purity Silica

• Consistent chromatographic performance

• Reliable run‑to‑run reproducibility

Important Usage Notes

• Designed for fast analytical screening and preparative method development

• Suitable for high aqueous mobile phases (including 100% water)

• Compatible with standard 4.6 mm HPLC systems

• Ideal when scalability and robustness are prioritized over maximum efficiency