Catalog Number - 84018-PG2

The 84018‑PG2 Cogent RP C18 PE™ Guard Column Cartridges are engineered to extend the life of analytical polar‑embedded HPLC columns, providing effective protection against particulates, strongly retained compounds, and sample matrix contamination during both routine analysis and preparative method development.

Packed with 10 µm Cogent RP C18 PE™ stationary phase and manufactured using high‑purity silica with a polar embedded amide group within a C18 ligand, these cartridges are fully double end‑capped to deliver:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Stable operation in high aqueous mobile phases, including 100% water

Each cartridge is constructed in a stainless steel tube with stainless steel frits, secured with PEEK frit caps for durability and reliable sealing.

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains chromatographic selectivity and method integrity

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained polar and non‑polar compounds

  • Sample matrix fouling

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and column replacement costs

10 µm Guard Media – Preparative Scouting Compatibility

• Designed for high‑flow and high‑load analytical workflows

• Provides durable performance during method development and scale‑up

• Ideal for PE method scouting prior to preparative chromatography

✅ Preferred when robustness and scalability are prioritized over efficiency

Why Choose RP C18 PE™ Guard Cartridges (10 µm)

Matched Polar Embedded Chemistry

• Same RP C18 PE™ stationary phase as analytical columns

• Maintains polar retention and method selectivity

• Prevents chromatographic variability

Enhanced Column Protection

• Captures particulates and strongly retained compounds before reaching the column

• Reduces column fouling and degradation

Workflow Efficiency

• Minimizes downtime and column replacement frequency

• Supports high‑throughput method development and QC workflows

Cogent RP C18 PE™ Advantages

Polar Embedded Ligand

• Enhances interaction with polar analytes

• Maintains traditional C18 hydrophobic selectivity

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry and reproducibility

Durable Construction

• Stainless steel body and frits

• PEEK sealing components

• Designed for routine analytical and development workflows

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID columns)

• Ideal for method development and preparative scouting workflows

• Replace regularly to maintain optimal column protection and performance