Catalog Number - 84318-PG2

The 84318‑PG2 Cogent RP C18 PE™ Guard Column Cartridges are engineered to extend the life of analytical HPLC columns, delivering high‑efficiency protection against particulates, strongly retained analytes, and sample matrix fouling in routine and high‑performance workflows.

Packed with 3 µm Cogent RP C18 PE™ polar embedded stationary phase, featuring an amide group within a C18 ligand, and manufactured using high‑purity silica with full double end‑capping, these cartridges provide:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Stable performance under high aqueous mobile phases, including 100% water

Each cartridge is constructed in a stainless steel tube with stainless steel frits, secured with PEEK frit caps to ensure durability and reliable sealing.

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains method integrity and chromatographic consistency

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained polar and non‑polar compounds

  • Sample matrix buildup and fouling

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and replacement costs

3 µm Guard Media – High‑Efficiency Protection

• Matches high‑efficiency analytical column particle sizes

• Preserves resolution and chromatographic performance

• Ideal for method development, QC, and regulated workflows

✅ Provides maximum protection with minimal impact on column efficiency

Why Choose RP C18 PE™ Guard Cartridges (3 µm)

Matched Polar Embedded Chemistry

• Same RP C18 PE™ stationary phase as analytical column

• Maintains polar retention behavior and selectivity

• Prevents chromatographic variability

Enhanced Column Protection

• Captures contaminants before reaching the main column

• Reduces irreversible binding and column degradation

Workflow Efficiency

• Minimizes column replacement frequency

• Supports high‑throughput analytical laboratories

Cogent RP C18 PE™ Advantages

Polar Embedded Ligand

• Enhances interaction with polar analytes

• Maintains traditional C18 hydrophobic selectivity

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry and reproducibility

Durable Construction

• Stainless steel body and frits

• PEEK sealing system

• Designed for routine analytical use

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID columns)

• Replace regularly to maintain optimal chromatographic performance

• Essential for protecting high‑value analytical columns