Catalog Number - 84518-PG1

The 84518‑PG1 Cogent RP C18 PE™ Guard Column Cartridges are engineered to extend the life of narrow‑bore LC‑MS and analytical HPLC columns, providing durable protection against particulates, strongly retained analytes, and sample matrix fouling in routine and high‑throughput workflows.

Packed with 5 µm Cogent RP C18 PE™ polar embedded stationary phase, incorporating an amide group within a C18 ligand, and manufactured on high‑purity silica with full double end‑capping, these cartridges provide:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Stable performance under high aqueous mobile phases, including 100% water

Each cartridge is constructed in a stainless steel tube with stainless steel frits, secured with PEEK frit caps to ensure durability and leak‑free operation in low‑flow systems.

Designed for 2.1 mm ID Columns (LC‑MS / Low Flow)

• Optimized for:

  • 2.1 mm ID LC‑MS columns

  • low‑flow analytical HPLC systems

✅ Maintains chromatographic integrity at low flow rates (~0.2–0.3 mL/min) ✅ Ideal for high‑sensitivity LC‑MS applications

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained polar and non‑polar analytes

  • Matrix buildup and fouling

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and replacement costs

5 µm Guard Media – Robust & Reliable Protection

• Matches standard analytical column particle size

• Provides balanced efficiency and durability

• Ideal for routine LC‑MS and analytical workflows

✅ Preferred for consistent performance and method reproducibility across systems

Why Choose RP C18 PE™ Guard Cartridges (5 µm)

Matched Polar Embedded Chemistry

• Same PE stationary phase as analytical columns

• Maintains polar retention and method selectivity

• Prevents chromatographic variability

Enhanced LC‑MS System Protection

• Reduces contaminants entering the column and detector

• Protects high‑value LC‑MS systems and narrow‑bore columns

Workflow Efficiency

• Minimizes column replacement frequency

• Improves instrument uptime and analytical throughput

Cogent RP C18 PE™ Advantages

Polar Embedded Ligand

• Enhances interaction with polar analytes

• Maintains traditional C18 hydrophobic selectivity

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry and reproducibility

Precision Construction

• Stainless steel cartridge body and frits

• PEEK sealing system

• Designed for low‑flow analytical and LC‑MS compatibility

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed specifically for 2.1 mm LC‑MS and low‑flow HPLC systems

• Requires stable low‑flow pump and low‑volume detector compatibility

• Replace regularly to maintain optimal protection and chromatographic performance