Catalog Number - 82361-PG2-3

Cogent NP Silica™ Wide Pore Guard Column Cartridges are designed to protect analytical HPLC columns from particulate contamination, strongly retained compounds, and sample matrix components that can shorten column life and reduce chromatographic performance. Packed with ultra-high purity, low metal content 300Å NP Silica™ stationary phase that is not chemically modified, these guard cartridges provide matching selectivity to the analytical column while serving as a sacrificial protection device.

82361-PG2-3 Guard Column Cartridges are packed with 3 µm NP Silica™ Wide Pore media in a 4.0 mm ID x 10 mm format and are designed to protect 3.0 mm, 4.0 mm, and 4.6 mm ID NP Silica™ Wide Pore analytical columns. The 300Å pore structure provides improved accessibility for larger molecules while preventing contaminants and particulates from reaching the analytical column. Routine use helps maintain column efficiency, improve reproducibility, and reduce analytical column replacement costs.

NP Silica™ Wide Pore guard cartridges are commonly used with HILIC and Normal Phase chromatography methods involving proteins, peptides, biomolecules, and other large hydrophilic or polar compounds. The matching stationary phase chemistry preserves chromatographic selectivity and method consistency while extending analytical column lifetime. For proper installation and operation, these cartridges must be used with a compatible Cogent Guard Column Holder.

Key Benefits

• NP Silica™ Wide Pore stationary phase

• USP L3 equivalent chemistry

• Ultra-high purity silica

• Low metal content silica

• Unmodified silica surface

• 300Å wide pore design

• 3 µm particle size

• Protects analytical columns from contamination

• Extends analytical column life

• Compatible with 3.0 mm, 4.0 mm, and 4.6 mm ID columns

Typical Applications

• HILIC chromatography

• Normal Phase HPLC

• USP L3 methods

• Protein analysis

• Peptide analysis

• Biomolecule separations

• Large molecule analysis

• Column protection

• Method development

• Pharmaceutical and biotechnology analyses

Specifications

• Product Type: Guard Column Cartridges

• Stationary Phase: NP Silica™ Wide Pore

• USP Classification: L3

• Particle Size: 3 µm

• Pore Size: 300Å

• Cartridge Dimensions: 4.0 mm ID x 10 mm

• Compatible Column IDs: 3.0 mm, 4.0 mm, and 4.6 mm

• Quantity: 5 Cartridges per Pack

• Cartridge Housing: Stainless Steel

• Frit Material: Stainless Steel Frits with PEEK Frit Caps

• Brand: Cogent

Required Guard Column Holder

• A Cogent Guard Column Holder (Catalog Number 83000-GH) is required for use with these guard column cartridges.

• See the Cogent Guard Column Holder (83000-GH) product page for complete holder specifications and ordering information.

Important Notes

• Designed for 3.0 mm, 4.0 mm, and 4.6 mm ID NP Silica™ Wide Pore analytical columns

• Suitable for HILIC and Normal Phase chromatography

• USP L3 equivalent chemistry

• Unmodified silica stationary phase

• Low metal content, high-purity silica

• Wide pore 300Å silica provides improved accessibility for larger molecules

• Protects analytical columns from particulates and strongly retained contaminants

• Helps extend analytical column lifetime

• Maintains method reproducibility and chromatographic performance

• Must be used with a Cogent Guard Column Holder (83000-GH)

• Supplied as a pack of 5 cartridges

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