Guard Column Starter Set, Silica-C, complete with 5 each 4.0 mm ID x 10 mm long cartridges packed with 4 um, 100 A phase and 1 each guard column holder. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40000‑PG4 Silica‑C™ Guard Column Starter Set provides everything needed to implement Cogent TYPE‑C™ guard column protection for larger‑ID analytical HPLC methods using Silica‑C™ chemistry. This complete starter kit is designed to protect analytical columns from particulates, strongly retained contaminants, and matrix components that can degrade performance and shorten column life.
The kit includes a stainless‑steel guard cartridge column holder compatible with all TYPE‑C™ guard cartridges, along with five Silica‑C™ guard cartridges packed with 4 µm, 100 Å Silica‑C™ stationary phase.
Guard Column Use Case: Silica‑C™ Protection for Larger‑ID Analytical Methods
Guard columns act as a sacrificial protection stage installed upstream of the analytical column. When running HILIC or normal‑phase methods with Silica‑C™ chemistry on 3.0–4.6 mm ID columns, guard columns help:
Protect analytical columns from particulate contamination
Trap strongly retained or irreversible sample components
Preserve chromatographic selectivity, peak shape, and retention stability
Extend analytical column lifetime and reduce replacement costs
Routine guard use helps maintain consistent performance in demanding analytical workflows.
What’s Included in the Starter Set
This guard column starter kit includes:
5 Silica‑C™ guard cartridges, each 4.0 mm ID × 10 mm length, packed with 4 µm, 100 Å Silica‑C™ phase
Based on average analytical use, the five included cartridges typically provide sufficient protection for the lifetime of one analytical column.
Each guard cartridge is shipped in an individual, closeable Delrin® storage case to prevent drying, contamination, or handling damage prior to installation.
Phase Consistency: Silica‑C™ TYPE‑C™ Chemistry
The guard cartridges in this kit are packed with the same Silica‑C™ TYPE‑C™ silica hydride chemistry used in corresponding analytical columns, ensuring:
No change in chromatographic selectivity or elution order
Minimal added dead volume
Seamless integration into existing Silica‑C™ methods
Stable performance under HILIC and normal‑phase conditions
Phase consistency is essential to preserve method integrity when using guard protection.
Compatibility & Recommended Use
Designed for 3.0 mm, 4.0 mm, and 4.6 mm ID analytical HPLC columns
Compatible with Cogent TYPE‑C™ analytical columns
Suitable for HILIC and normal‑phase workflows using Silica‑C™ chemistry
This starter set is ideal for laboratories implementing guard protection on larger‑diameter analytical columns or standardizing guard usage across multiple methods.
Operational Notes
Guard cartridges are easily replaced without removing the analytical column
Replacement frequency depends on sample cleanliness and matrix complexity
Guard use is strongly recommended for LC‑MS, biological, and complex sample matrices