Catalog Number - 40031-PG2

40031-PG2 Cogent UDA™ (WCX) Guard Column Cartridges are designed to protect analytical columns from particulates and strongly retained contaminants that can degrade column performance and shorten lifespan.

Each cartridge is packed with 4 µm, 100 Å Cogent UDA™ stationary phase, built on TYPE‑C™ silica (silica hydride platform). The UDA™ ligand (Undecanoic Acid) features an 11‑carbon hydrophobic chain with a terminal carboxylic acid group, enabling:

• Reversed phase (hydrophobic retention)

• Weak cation exchange (active at pH ≥ 6)

• HILIC (polar interaction capability)

Using matched chemistry ensures that contaminants are trapped while chromatographic selectivity remains unchanged, preserving method integrity and reproducibility.

Each cartridge is packed in a stainless steel tube with stainless steel frits, and individually sealed in protective Delrin storage cases to prevent drying and contamination prior to use.

✅ Required Hardware: These guard cartridges must be used with a Cogent Guard Column Holder (click here for holder information and compatibility details)

2.0 mm ID × 10 mm Length – Low‑Dispersion Column Protection

Designed for narrow‑bore analytical LC systems.

• Compatible with 2.1 mm ID analytical columns

• Minimizes band broadening in low‑volume systems

• Protects against particulates and matrix contamination

• Maintains resolution and analytical performance

✅ Recommended for LC‑MS and UHPLC workflows using 2.1 mm ID columns

Flow Rate & System Requirements (2.1 mm ID, 4 µm)

⚠️ Requires low‑flow capable HPLC or UHPLC system

• Typical flow rate range: ~0.2 – 0.4 mL/min

• Moderate backpressure

• Designed for low‑dispersion analytical systems

• Compatible with UV and MS detection

✅ Important: Systems must deliver stable, precise low‑flow rates

✅ Best Practice: Replace cartridges regularly to maintain system performance and extend analytical column lifetime

Why Use UDA™ Guard Column Cartridge

Column Protection

• Prevents buildup of particulates and strongly retained contaminants

• Reduces irreversible adsorption on analytical columns

Maintains Selectivity

• Matched UDA™ chemistry ensures consistent chromatographic behavior

• Preserves method reproducibility

Extends Column Life

• Reduces frequency of analytical column replacement

• Improves workflow efficiency

TYPE‑C Silica Advantages

Faster Equilibration

• Reduces downtime between runs

No Strict Moisture Control (HILIC)

• Simplifies mobile phase handling

Extreme Robustness

• Stable at low pH (<2)

• Resistant to hydrolysis

Long Cartridge Life

• Durable for routine analytical workflows

Cogent UDA™ Guard Cartridge Advantages

Matched Mixed‑Mode Chemistry

• RP, HILIC, and WCX selectivity maintained

Low‑Dispersion Design

• Ideal for LC‑MS systems

Durable Construction

• Stainless steel body with protective storage cases

Typical Applications

• LC‑MS and UHPLC workflows

• Complex matrix separations

• Method development and routine analysis

• Basic and ionizable compound analysis

• Pharmaceutical and bioanalytical testing

Important Usage Notes

• Use with a compatible guard column holder (sold separately)

• Designed for 2.1 mm ID analytical columns

• Packed and shipped in reversed‑phase solvents

• Replace cartridges when pressure increases or performance declines