Catalog Number - 58846-03-002

58846-03-002 ARE‑Applied Research Mobile Phase Inlet Filters are high‑performance, biocompatible solvent filtration devices engineered for HPLC, UHPLC, and LC‑MS mobile phase delivery systems, providing high throughput, solvent efficiency, and critical system protection.

These filters use a “Last Drop” flat‑profile design, enabling near‑complete use of the mobile phase in reservoir bottles. This design is particularly beneficial for long analytical sequences, overnight runs, and high‑value solvent systems, where minimizing waste and ensuring uninterrupted flow is essential.

Each filter is manufactured with a 2.5 µm PTFE filter element and an inert PEEK / PTFE wetted flow path, delivering exceptional chemical compatibility, low extractables, and biocompatibility for sensitive analytical workflows.

“Last Drop” Design – Maximum Solvent Utilization

• Wide 22 mm flat filter geometry

• Seats at the lowest point in the bottle

• Draws solvent to near‑empty conditions

• Reduces waste and prevents system interruption

✅ Ideal for long runs, high‑throughput labs, and costly solvents

✅ Improves efficiency and consistency of analytical workflows

2.5 µm PTFE Element – Biocompatible Filtration

• Removes particles ≥ 2.5 µm

• Protects:

  • Pump seals and check valves

  • Injector systems

  • Columns and detectors

• PTFE media provides:

  • Broad chemical compatibility

  • Biocompatibility for sensitive applications

  • Low adsorption and extractables

✅ Ideal for LC‑MS, pharmaceutical, and bioanalytical workflows

Visual Inspection Advantage – White Filter Element

• White PTFE surface allows easy visibility of trapped particles

• Enables quick assessment of filter condition

• Helps determine when replacement is required

✅ Supports proactive maintenance and stable performance

PEEK / PTFE Flow Path – High Purity Performance

• All wetted components made from:

  • PEEK (polyether ether ketone)

  • PTFE (inert fluoropolymer)

• Provides:

  • Chemical inertness

  • Low extractables

  • Consistent solvent compatibility

✅ Suitable for high‑purity analytical and LC‑MS applications

1/8" Connector with ETFE Ferrule – High‑Flow Integration

• Integrated 1/8" tubing connector

• Includes ETFE ferrule for secure, leak‑free sealing

• Designed for non‑flanged low‑pressure tubing

• No additional fittings required

✅ Ideal for higher flow rate systems and larger tubing configurations

Performance Advantages – Modern HPLC Operation

Compared to conventional inlet filters:

• Maximizes usable solvent volume

• Reduces risk of air entering pump systems

• Improves flow consistency at low solvent levels

• Supports long, unattended analytical runs

✅ Aligns with current best practices in chromatography system protection

System Compatibility & Use

Designed for use with:

• HPLC / UHPLC mobile phase systems

• LC‑MS solvent delivery setups

• Low‑pressure tubing systems (1/8")

• Standard mobile phase reservoir bottles

✅ Installs directly into mobile phase bottles for inline filtration

Typical Applications

• HPLC mobile phase filtration

• LC‑MS solvent protection

• Biocompatible analytical workflows

• High‑throughput laboratories

• Extended and overnight chromatographic runs

• Integrated into original equipment manufacturer (OEM) product designs

Important Usage Notes

• Designed for low‑pressure systems only

• Ensure tubing is properly seated with ferrule

• Inspect for particle buildup regularly

• Replace filter element as flow restriction increases