Catalog Number - 40218-PG3

The 40218‑PG3 Cogent Bidentate C18™ 2.o Guard Column Cartridge is a single replacement guard cartridge designed to protect 2.1 mm ID Cogent TYPE‑C™ analytical HPLC columns operating under high‑efficiency and near‑UHPLC conditions. This cartridge is phase‑matched to Bidentate C18™ 2.o analytical columns to preserve retention, selectivity, and peak efficiency while trapping particulates and strongly retained contaminants.

Each cartridge is packed with Cogent Bidentate C18™ 2.o stationary phase (2.2 µm, 120 Å) and housed in a stainless‑steel tube with stainless‑steel frits, providing excellent mechanical stability and pressure tolerance for demanding analytical workflows. The cartridge is individually labeled and shipped in a protective black Delrin case to prevent drying, contamination, or physical damage prior to installation.

This cartridge is used with a compatible Cogent TYPE‑C™ guard column holder, sold separately.

Single cartridges are often preferred when laboratories run multiple analytical methods and want the flexibility to pair different guard phases with different analytical columns—without committing to a multi‑pack.

Why Use a Single Bidentate C18™ 2.o Guard Cartridge?

High‑efficiency methods place increased stress on column frits and packing. Proper guard protection helps to:

• Capture undissolved sample particulates

• Trap strongly retained matrix contaminants

• Preserve peak shape, resolution, and retention stability

• Extend the service life of high‑value 2.2 µm analytical columns

Using a single replacement cartridge enables targeted, method‑specific replacement with minimal downtime and no disturbance to the analytical column.

Product Details

• Internal diameter: 2.0 mm

• Length: 10 mm

• Particle size: 2.2 µm

• Pore size: 120 Å

• Phase: Cogent TYPE‑C™ Bidentate C18™ 2.o

• Housing: Stainless steel tube with stainless‑steel frits

Key Features

Phase‑Matched High‑Efficiency Protection

• Same Bidentate C18™ 2.o TYPE‑C™ chemistry as analytical columns

• Maintains selectivity, retention, and efficiency

• Avoids artifacts from mismatched guard phases

Designed for 2.1 mm ID Columns

• Optimized for 2.1 mm low‑flow and LC‑MS workflows

• Suitable for near‑UHPLC performance on standard HPLC systems

Durable Stainless‑Steel Construction

• High‑pressure‑capable stainless‑steel body and frits

• Reliable sealing with consistent flow

• Appropriate for routine high‑performance analytical use

Flexible Purchasing Option

• Single‑cartridge format for method‑specific needs

• Ideal when multiple guard chemistries are used

• Easy replacement using an existing guard holder

Typical Applications

• High‑efficiency analytical HPLC

• Near‑UHPLC methods using 2.2 µm particles

• LC‑MS and LC‑MS/MS

• Method development and validation

• Protection of TYPE‑C™ Bidentate C18™ 2.o analytical columns

.