Guard Column Starter Set, Silica-C 2.o, complete with 5 each 2.0 mm ID x 10 mm long cartridges packed with 2.2 um, 120 A phase and 1 each guard column holder. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40200‑PG1 Silica‑C™ 2.o Guard Column Starter Set provides everything needed to implement high‑pressure Cogent TYPE‑C™ guard column protection for Silica‑C™ 2.o analytical HPLC methods. This complete starter kit is designed to protect analytical columns from particulates, strongly retained contaminants, and matrix components that can degrade performance and shorten column life—especially in small‑particle, high‑pressure workflows.
The kit includes a stainless‑steel guard cartridge column holder suitable for high‑pressure operation, along with five Silica‑C™ 2.o guard cartridges packed with 2.2 µm, 120 Å Silica‑C™ 2.o stationary phase.
Guard Column Use Case: Silica‑C™ 2.o Protection for High‑Pressure Analytical Methods
Guard columns act as a sacrificial protection stage installed upstream of the analytical column. When running HILIC or normal‑phase methods with Silica‑C™ 2.o chemistry, guard columns help:
Protect analytical columns from particulate contamination
Trap strongly retained or irreversible sample components
Preserve chromatographic selectivity, peak shape, and retention stability
Extend analytical column lifetime and reduce replacement costs
Guard usage is particularly important for 2.2 µm particle columns, where contamination can have a larger impact on performance.
What’s Included in the Starter Set
This guard column starter kit includes:
1 stainless‑steel guard cartridge column holder designed for high‑pressure use
5 Silica‑C™ 2.o guard cartridges, each 2.0 mm ID × 10 mm length, packed with 2.2 µm, 120 Å Silica‑C™ 2.o phase
Based on average analytical use, the five included cartridges typically provide sufficient protection for the lifetime of one analytical column.
Each guard cartridge is shipped in an individual, closeable Delrin® storage case to prevent drying, contamination, or handling damage prior to installation.
Phase Consistency: Silica‑C™ 2.o TYPE‑C™ Chemistry
The guard cartridges in this kit are packed with the same Silica‑C™ 2.o TYPE‑C™ silica hydride chemistry used in corresponding analytical columns, ensuring:
No change in chromatographic selectivity or elution order
Minimal added dead volume
Seamless integration into existing Silica‑C™ 2.o methods
Stable performance under HILIC and normal‑phase conditions
Maintaining phase consistency is essential for preserving method integrity when using guard protection in high‑pressure workflows.
Compatibility & Recommended Use
Designed for 2.1 mm ID analytical HPLC columns
Compatible with Cogent TYPE‑C™ analytical columns
Suitable for HILIC and normal‑phase workflows using Silica‑C™ 2.o chemistry
This starter set is ideal for laboratories implementing guard protection for small‑particle, high‑pressure analytical methods or standardizing guard usage across Silica‑C™ 2.o workflows.
Operational Notes
Guard cartridges are easily replaced without removing the analytical column
Replacement frequency depends on sample cleanliness and matrix complexity
Guard use is strongly recommended for LC‑MS, biological, and complex sample matrices, particularly with 2.2 µm particle columns