Safety‑coated mobile‑phase bottles are designed to reduce glass hazards during solvent handling in chromatography laboratories while maintaining the chemical performance of high‑quality borosilicate glass. This category includes externally only coated glass solvent reservoirs used for HPLC, UHPLC, and LC‑MS mobile‑phase delivery in environments where enhanced safety controls are required.
These bottles are constructed from Type‑33 borosilicate glass and feature a protective, proprietary polymer coating applied only to the exterior surface. The internal glass surface remains uncoated and chemically inert, preserving solvent purity, minimizing extractables, and maintaining compatibility with aqueous and organic mobile phases.
Safety‑Focused Design
The external safety coating is designed to help contain glass fragments and liquid if the bottle is accidentally dropped or impacted. This added layer of protection supports safer handling of mobile‑phase solvents, particularly in laboratories working with large reservoir volumes, frequent bottle changes, or high‑traffic work areas.
Because the coating is applied only to the outside of the bottle, it does not affect solvent contact, gas permeability, or chromatographic performance.
Material & Performance Characteristics
Type‑33 borosilicate glass interior for chemical resistance and dimensional stability
Low leachables and extractables, suitable for sensitive chromatographic workflows
Effective gas‑barrier properties to support solvent integrity
External polymer safety coating for impact and splash mitigation
These characteristics allow safety‑coated bottles to deliver the same analytical performance as non‑coated bottles while providing additional protection for personnel and equipment.
Configurations & Compatibility
Safety‑coated mobile‑phase bottles in this category are available in:
Clear glass formats for visual solvent inspection
Standard taper (29/32) necks and GL‑threaded necks (e.g., GL45)
Common reservoir sizes, including 1 L, 2 L, 5 L, and 10 L capacities
Selected GL‑threaded bottles are supplied with drip rings and inert screw caps, supporting compatibility with mobile‑phase filtration devices, solvent pickup assemblies, and common chromatography fittings.
Temperature & Handling Considerations
Borosilicate glass supports a wide range of laboratory temperatures
Polypropylene caps are suitable for temperatures up to 140 °C
Safety‑coated bottles are not intended for autoclaving by heat, due to the external coating
Laboratories should select safety‑coated bottles when handling protection is a priority and non‑coated bottles when repeated heat sterilization is required.
Typical Applications
Safety‑coated HPLC mobile‑phase bottles are commonly used for:
Solvent reservoirs in HPLC and UHPLC systems
LC‑MS mobile‑phase delivery at larger volumes
Laboratories with enhanced safety or spill‑mitigation protocols
Shared laboratory spaces or high‑throughput environments
Visit page for non-coated, economical solvent reservoir bottles that can be autoclaved if desired.
