Overview
Cogent pre‑column filters are manufactured using a high‑purity PEEK housing and a stainless‑steel internal filter element. While stainless steel is broadly solvent‑resistant, PEEK has known chemical compatibility limitations.
To ensure safe operation and preserve the integrity of the filter, it is essential to avoid solvents that can degrade or damage PEEK components.
Solvents That Should NOT Be Used
Any solvent incompatible with PEEK should not be used with Cogent Column Filters. These include, but are not limited to:
- DMSO (Dimethyl sulfoxide)
- Methylene chloride (Dichloromethane)
- Concentrated THF (Tetrahydrofuran)
These solvents can cause swelling, softening, or chemical attack of PEEK, leading to compromised sealing, structural instability, or leakage under pressure.
Why PEEK Incompatibility Matters
Using incompatible solvents may result in:
- Deformation or cracking of the PEEK housing
- Loss of mechanical strength
- Leakage or failure under system pressure
- Contamination of downstream components
- Shortened service life of the filter and potentially the column
To maintain safe operation, always verify solvent compatibility with PEEK when designing or modifying HPLC methods.
Recommended Best Practices
- Review solvent compatibility charts for PEEK before use
- Avoid prolonged exposure to borderline or aggressive solvents
- If high‑strength or incompatible solvents are required, consider alternate filtration materials or configurations.
