Introduction

Mobile phase reservoir bottles are routinely used in HPLC, UHPLC, and LC-MS laboratories for solvent storage, buffer preparation, and mobile phase delivery. In addition to chemical compatibility, temperature performance is an important consideration when selecting laboratory glassware for analytical applications.

Non-coated mobile phase reservoir bottles are manufactured from laboratory glass with a low coefficient of thermal expansion, allowing them to withstand significant temperature changes while maintaining dimensional stability and resistance to thermal stress.

What Makes These Bottles Temperature Resistant?

One of the key properties of non-coated mobile phase reservoir bottles is their low coefficient of thermal expansion of 3.3.

A low thermal expansion value means the glass expands and contracts less when exposed to changing temperatures. This characteristic helps reduce stress within the glass and improves resistance to thermal shock when compared to many common laboratory glass materials.  As a result, these bottles can tolerate substantial temperature variations encountered in analytical laboratories.

Temperature Range

Non-coated mobile phase reservoir bottles are suitable for use across a broad temperature range:  -70°C to 500°C

This wide operating range supports numerous laboratory applications involving both low-temperature storage and elevated-temperature processing.

Advantages of Low Thermal Expansion Glass

The low thermal expansion characteristics provide several practical benefits:

• Improved resistance to thermal shock
• Increased dimensional stability
• Reduced stress during heating and cooling cycles
• Enhanced durability during routine laboratory use
• Compatibility with a wide range of temperature-controlled applications

These properties make the bottles suitable for environments where rapid or repeated temperature changes may occur.

Common Laboratory Applications

Because of their temperature performance, non-coated mobile phase reservoir bottles are often used in:

• HPLC mobile phase preparation
• UHPLC solvent storage
• LC-MS solvent reservoirs
• Freezer storage applications
• Refrigerated sample storage
• Laboratory heating procedures
• Buffer preparation workflows

Their versatility makes them suitable for both routine and specialized analytical laboratory operations.

Compatibility with Sterilization and Temperature Controlled Equipment

The thermal characteristics of low-expansion laboratory glass allow these bottles to be used in various temperature-controlled environments, including:

• Freezers
• Autoclaves
• Dry heat sterilization chambers
• Microwave-assisted laboratory applications

When using elevated temperatures, always verify that bottle caps, closures, and accessories are compatible with the intended operating conditions.

Important Considerations

Although the glass bottle itself may tolerate a broad temperature range, the complete bottle assembly may have additional limitations.

Before use, verify the temperature specifications of:

• Bottle caps
• Tubing assemblies
• Filters
• Solvent inlet components
• Closure accessories

The overall temperature capability of the assembly is typically limited by the lowest-rated component.

Conclusion

Non-coated mobile phase reservoir bottles provide excellent temperature performance due to their low coefficient of thermal expansion. With an operating range from -70°C to 500°C, these bottles are suitable for a variety of chromatography, solvent handling, storage, and laboratory preparation applications. Their resistance to thermal stress helps support reliable performance in freezers, autoclaves, sterilization equipment, and routine analytical workflows.