Catalog Number - 58022-N04-A

The 58022-N04-A AQ™ Syringe Filters are pharmaceutical-grade, ultra-low volume membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm Nylon‑66 membrane, these filters deliver exceptional consistency, ultra-low adsorption, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results—even with very limited sample volumes.

The 4 mm format is specifically designed for micro-volume filtration, minimizing hold-up volume and maximizing recovery from extremely valuable or limited samples, making it ideal for LC‑MS workflows and precision analytical methods.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 210.3(b)(6) for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 20 µL of filtrate

• ✅ Preserves extremely valuable micro-volume samples

• ✅ Saves time and reduces risk of failed methods and investigations

👉 This provides a critical operational and compliance advantage for QC/QA laboratories and LC‑MS users, where every microliter matters and method reliability is essential.

Performance & Design

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical systems.

Nylon‑66 membrane chemistry offers broad compatibility with aqueous and organic HPLC solvents, while maintaining ultra-low adsorption—even for charged analytes, ensuring accurate quantitation.

The 4 mm design minimizes hold-up volume, maximizing recovery from small or high-value samples, making it ideal for micro-sample preparation and sensitive analytical workflows.

The purple color coding allows quick identification of 0.22 µm nylon filters, and each pack includes a Certificate of Analysis for full traceability, compliance, and audit readiness.

Key Features

0.22 µm Nylon‑66 Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Ensures maximum sample clarity

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• No 20 µL discard required

Ultra-Low Adsorption

• Suitable for charged and sensitive analytes

• Maximizes analyte recovery

Ultra-Low Volume Format (4 mm)

• Minimizes hold-up volume

• Maximizes recovery from micro-volume samples

Regulatory Compliance

• Meets FDA CFR Title 21 requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

Broad Solvent Compatibility

• Compatible with aqueous and organic solvents

• Ideal for mixed HPLC and LC‑MS workflows

Autoclavable & EO Sterilizable

• 121°C for 30 minutes or Ethylene Oxide

Color-Coded (Purple)

• Identifies 0.22 µm nylon filters

Typical Applications

• HPLC & UHPLC Sample Preparation – micro-volume fine filtration

• LC‑MS Workflows – maximum recovery with minimal loss

• Sterile Filtration – bacterial and particulate removal

• Method Development – limited or high-value samples

• Dissolution Testing – pharmaceutical QC workflows

• Regulated Laboratory Methods – validated, compliant processes

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: Nylon‑66

• Pore Size: 0.22 µm

• Diameter: 4 mm

• Housing Material: Polypropylene (PP)

• Color Code: Purple (0.22 µm Nylon)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Aqueous and organic solvents

• Extractables: None detectable (no flush required)

• Initial Discard Volume: None (20 µL not required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21, USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 50/PK

• Brand: AQ™

Resources & Ordering Options

• Order Nylon‑66 syringe filters, 0.22 µm, 4 mm – 1000/case quantity

• Purchase Nylon‑66 syringe filters, 0.22 µm, 4 mm – 100/pack quantity