Syringe Filters, 4mm, Nylon, 0.22um Pore Size. Purple Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58022-N04-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput micro-volume membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm Nylon‑66 membrane, these filters deliver exceptional consistency, ultra-low adsorption, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results in high-volume workflows.
The 4 mm format is specifically designed for ultra-low volume filtration, minimizing hold-up volume and maximizing recovery from extremely limited or high-value samples, making them ideal for LC‑MS and precision analytical applications.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 210.3(b)(6) for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 20 µL of filtrate
✅ Preserves extremely valuable micro-volume samples
✅ Saves time and reduces risk of failed methods and costly investigations
👉 This provides a critical operational and compliance advantage for QC/QA laboratories and LC‑MS users, where every microliter matters and reproducibility is essential.
Performance & Design
The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical instrumentation.
Nylon‑66 membrane chemistry ensures broad compatibility with aqueous and organic HPLC solvents, while maintaining ultra-low adsorption—even for charged analytes, supporting accurate quantitation.
The 4 mm design minimizes hold-up volume, maximizing recovery from small or high-value samples, making it ideal for micro-sample preparation, LC‑MS workflows, and method development.
The purple color coding enables rapid identification of 0.22 µm nylon filters, and each case includes a Certificate of Analysis for full traceability, compliance, and audit readiness.
Key Features
0.22 µm Nylon‑66 Membrane (Pharma Grade)
Ideal for sterile filtration and fine particulate removal
Ensures maximum sample clarity and protection
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 20 µL discard required
Ultra-Low Adsorption
Suitable for charged and sensitive analytes
Maximizes analyte recovery
Ultra-Low Volume Format (4 mm)
Minimizes hold-up volume
Maximizes recovery from micro-volume samples
Regulatory Compliance
Meets FDA CFR Title 21 requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Broad Solvent Compatibility
Compatible with aqueous and organic solvents
Ideal for HPLC and LC‑MS workflows
Autoclavable & EO Sterilizable
121°C for 30 minutes or Ethylene Oxide
Color-Coded (Purple)
Identifies 0.22 µm nylon filters
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-throughput labs
Typical Applications
HPLC & UHPLC Sample Preparation – micro-volume fine filtration
LC‑MS Workflows – maximum recovery with minimal loss
Sterile Filtration – bacterial and particulate removal
Method Development – limited or high-value samples
Dissolution Testing – pharmaceutical QC workflows
Regulated Laboratory Methods – validated, compliant processes
Specifications
Filter Type: Syringe Filter (Pharma Grade)
Membrane Material: Nylon‑66
Pore Size: 0.22 µm
Diameter: 4 mm
Housing Material: Polypropylene (PP)
Color Code: Purple (0.22 µm Nylon)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Aqueous and organic solvents
Extractables: None detectable (no flush required)
Initial Discard Volume: None (20 µL not required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21, USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options