Catalog Number - 58022-P13-A

The 58022-P13-A AQ™ Syringe Filters are pharmaceutical-grade, high-performance membrane filters designed for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm PTFE (Polytetrafluoroethylene) membrane, these filters provide exceptional chemical resistance, sterile filtration capability, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results.

PTFE membranes are the preferred choice for organic solvent systems, offering superior resistance to aggressive solvents, acids, and bases, making them ideal for demanding analytical workflows.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 211.92 for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 200 µL of filtrate

• ✅ Preserves valuable samples

• ✅ Eliminates a common source of failed methods and investigations

👉 This provides a strong operational and compliance advantage for QC/QA laboratories, especially in sterile filtration workflows using organic solvents.

Performance & Design

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical systems.

PTFE membrane chemistry provides maximum chemical compatibility, ensuring stable performance in organic solvents, strong acids, and alkaline conditions, without degradation.

⚠️ Important: PTFE membranes are hydrophobic and not recommended for 100% aqueous or buffer solutions, making them best suited for organic or mixed-phase solvent systems requiring sterile filtration.

The 13 mm format is ideal for low to moderate sample volumes, offering efficient filtration with minimal waste, making it suitable for routine laboratory workflows and sample-limited applications.

The blue housing allows quick identification of 0.22 µm PTFE filters, and each pack includes a Certificate of Analysis for full traceability and compliance.

Key Features

0.22 µm PTFE Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Excellent chemical resistance

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• No 200 µL discard required

Superior Chemical Resistance

• Compatible with solvents, acids, and bases

• Will not degrade under harsh conditions

⚠️ Hydrophobic Membrane

• Not suitable for 100% aqueous solutions

• Designed for organic or mixed-phase applications

Sterile Filtration Capability

• Suitable for critical analytical and pharmaceutical workflows

Optimized for Moderate Volumes (13 mm)

• Efficient filtration with reduced waste

• Ideal for routine analytical work

Low Extractables

• Ensures clean chromatographic baselines

• Improves reproducibility

Regulatory Compliance

• Meets FDA CFR 21 (211.92) requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

Color-Coded (Blue)

• Identifies 0.22 µm PTFE filters

Typical Applications

• HPLC & UHPLC Sample Preparation – sterile filtration of organic solvents

• Pharmaceutical Analysis – dissolution and QC workflows

• Organic & Chemical Analysis – aggressive solvent systems

• Environmental Testing – non-aqueous sample filtration

• Routine Laboratory Workflows – moderate sample volumes

• Regulated Laboratory Methods – validated, compliant processes

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: PTFE (Polytetrafluoroethylene)

• Pore Size: 0.22 µm

• Diameter: 13 mm

• Housing Material: Polypropylene (PP)

• Color Code: Blue (0.22 µm PTFE)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Organic solvents, acids, bases

• Hydrophilicity: Hydrophobic (not for aqueous solutions)

• Extractables: None detectable (no flush required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21 (211.92), USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 50/PK

• Brand: AQ™

Resources & Ordering Options

• Purchase PTFE syringe filters, 0.22 µm, 13 mm – 100/pack quantity

• Order PTFE syringe filters, 0.22 µm, 13 mm – 1000/case quantity