Catalog Number - 58045-F25-C

The 58045-F25-C AQ™ Syringe Filters are pharmaceutical-grade, dual-layer membrane filters designed for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm Nylon 66 membrane with an integrated binder-free borosilicate glass fiber pre-filter, these filters deliver high loading capacity, fast flow rates, and reliable filtration of particulate-heavy samples.

Nylon membranes provide broad compatibility with aqueous and organic solvents, while the glass fiber pre-filter minimizes clogging, making these filters ideal for complex or dirty sample matrices requiring high throughput.

✅ Critical Compliance Advantage (No Flush Required)

Validated to meet key regulatory standards:

• US FDA CFR Title 21, Part 210.3(b)(6) – minimum fiber release

• USP <788> – particulate matter in injectables

• USP “Sterile Water for Injection”

Benefits:

• ✅ No initial flushing required

• ✅ No 200 µL discard required

• ✅ Extractable-free from first filtrate

• ✅ Reduces risk of failed methods

Performance & Design

The 0.45 µm Nylon membrane is optimized for sample clarification, while the integrated glass fiber pre-filter increases dirt-holding capacity and prevents premature clogging.

The 25 mm format supports higher sample volumes, making it well suited for routine and high-throughput workflows.

The 16-channel outlet design reduces back pressure, allowing smooth filtration with less hand force.

The white housing with green lettering enables easy identification, and each pack includes a Certificate of Analysis.

Key Features

0.45 µm Nylon Membrane with Glass Fiber Pre-Filter

• Ideal for particulate-heavy samples

• Combines filtration and prefiltration

✅ No Initial Flush Required (Validated)

• No 200 µL discard required

High Throughput Performance

• Increased loading capacity

• Faster filtration

Broad Solvent Compatibility

• Suitable for aqueous and organic solutions

Reduced Back Pressure

• Multi-channel outlet design

Prefiltration Capability

• Minimizes clogging

• Extends filter life

Regulatory Compliance

• FDA CFR 21, USP <788>

Color-Coded (White / Green)

• Identifies Nylon with pre-filter

Typical Applications

• HPLC & UHPLC Sample Preparation – particulate-heavy samples

• Dissolution Testing – complex matrices

• Environmental & Industrial Samples

• Pharmaceutical & Biological Samples

• High-Throughput Workflows

Specifications

• Membrane Material: Nylon 66 + Glass Fiber Pre-Filter

• Pore Size: 0.45 µm

• Diameter: 25 mm

• Housing: Polypropylene (PP)

• Color Code: White / Green

• Chemical Compatibility: Aqueous & organic solvents

• Extractables: None detectable (no flush required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21, USP <788>

• Pack Size: 100/PK

• Brand: AQ™

Resources & Ordering Options

• Purchase nylon syringe filters with glass pre-filter, 0.45 µm, 25 mm – 50/pack quantity

• Order nylon syringe filters with glass pre-filter, 0.45 µm, 25 mm – 1000/case quantity