Syringe Filters, 25mm, Nylon, 0.45um Pore Size with a Pre-Filter . White/Green Polypropylene, AQ Brand. 50/PK.
Additional Info:
The 58045-F25-A AQ™ Syringe Filters are pharmaceutical-grade, dual-layer membrane filters designed for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm Nylon 66 membrane with an integrated binder-free borosilicate glass fiber pre-filter, these filters provide enhanced loading capacity, faster flow rates, and improved performance for particulate-heavy samples.
Nylon membranes offer broad compatibility with aqueous and organic solvents, while the glass fiber pre-filter reduces clogging, making these filters ideal for dirty or complex sample matrices requiring high throughput.
✅ Critical Compliance Advantage (No Flush Required)
Validated to meet key regulatory standards:
US FDA CFR Title 21, Part 210.3(b)(6) – minimum fiber release
USP <788> – particulate matter in injectables
USP “Sterile Water for Injection”
Benefits:
✅ No initial flushing required
✅ No 200 µL discard required
✅ Extractable-free from first filtrate
✅ Reduces risk of failed methods
Performance & Design
The 0.45 µm Nylon membrane is optimized for sample clarification and general-purpose filtration, while the integrated glass fiber pre-filter increases dirt-holding capacity and prevents premature clogging.
The 25 mm format supports higher sample volumes, making this configuration ideal for high-throughput workflows and particulate-heavy samples.
The advanced multi-channel outlet design reduces back pressure, allowing smooth filtration with less hand force.
The white housing with green lettering enables quick identification, and each pack includes a Certificate of Analysis.
Key Features
0.45 µm Nylon Membrane with Glass Fiber Pre-Filter
Ideal for particulate-heavy samples
Combines filtration and prefiltration in one unit
✅ No Initial Flush Required (Validated)
No 200 µL discard required
High Throughput Design
Increased loading capacity
Faster flow rates
Broad Solvent Compatibility
Suitable for aqueous and organic solvents
Reduced Back Pressure
Multi-channel outlet design
Easier manual filtration
Prefiltration Capability
Protects membrane from clogging
Extends filter life
Regulatory Compliance
FDA CFR 21, USP <788>
Color-Coded (White / Green)
Identifies Nylon with pre-filter
Typical Applications
HPLC & UHPLC Sample Preparation – particulate-heavy samples
Dissolution Testing – complex matrices
Environmental & Industrial Samples
Biological & Pharmaceutical Samples
High-Throughput Laboratories – reduced clogging workflows
Specifications
Membrane Material: Nylon 66 + Glass Fiber Pre-Filter
Pore Size: 0.45 µm
Diameter: 25 mm
Housing: Polypropylene (PP)
Color Code: White / Green
Chemical Compatibility: Aqueous & organic solvents
Extractables: None detectable (no flush required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21, USP <788>
Pack Size: 50/PK
Brand: AQ™
Resources & Ordering Options
Purchase nylon syringe filters with glass pre-filter, 0.45 µm, 25 mm – 100/pack quantity
Order nylon syringe filters with glass pre-filter, 0.45 µm, 25 mm – 1000/case quantity