Prep HPLC Column, Bidentate C18, 4um, 100A. 21.2mm ID x 150mm Length. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40018‑P21‑150 Cogent Bidentate C18™ Preparative HPLC Column is a long‑format preparative column designed for workflows that require higher resolving power and improved fraction purity compared with shorter preparative lengths. Built on Cogent TYPE‑C™ silica hydride technology, this column provides excellent selectivity, fast equilibration, and very robust column lifetimes under demanding purification conditions.
The stationary phase utilizes an aliphatic C18 chain bonded via two direct silicon–carbon bonds (bidentate attachment) to a silica hydride surface. This non‑traditional reversed‑phase chemistry creates a phase that is highly hydrophobic yet versatile, enabling strong and stable retention of hydrophobic molecules, metabolites, and amine‑containing analytes. In contrast to conventional silica‑based prep C18 columns, the TYPE‑C™ hydride surface remains stable in aqueous‑dominant mobile phases and tolerates low‑pH conditions, expanding method flexibility for preparative workflows.
With a 21.2 mm internal diameter and an extended 150 mm length, this column delivers increased plate count and enhanced separation efficiency, making it especially useful when closely eluting impurities must be fully resolved prior to fraction collection.
System Note: A specialized preparative HPLC system (appropriate high‑flow pump capacity, injector, tubing/valving, and fraction‑collection hardware) is required for columns of this size and length.
Why Choose the 21.2 × 150 mm Prep Bidentate C18™ Format
This configuration is commonly selected when:
Higher purification resolution is required than 50 mm or 100 mm prep columns can provide
Sample loads are large and contain closely related components
Hydrophobic or basic analytes challenge traditional prep C18 materials
Method robustness and reproducibility are critical across repeated prep cycles
The longer length increases interaction time and selectivity while preserving the durability and rapid equilibration inherent to TYPE‑C™ silica hydride chemistry.
Key Features
Cogent TYPE‑C™ Silica Hydride Technology
Reduced silanol activity and secondary interactions
Faster equilibration than conventional prep C18 columns
Very robust lifetimes for repeated purification cycles
Bidentate C18™ Bonding
Two‑point attachment via direct Si–C bonds
Strong hydrophobic retention with versatile selectivity
Suitable for hydrophobic and amine‑containing analytes
Preparative Geometry with Enhanced Resolution
21.2 mm ID × 150 mm length
Higher plate count vs. shorter prep formats
Supports tighter fraction cuts and higher purity outcomes
Broad Operating Window
Compatible with aqueous‑dominant mobile phases
Stable under low‑pH conditions
Tolerates aggressive purification methods
Typical Applications
Preparative purification and fraction collection
Hydrophobic molecule and metabolite isolation
Amine‑containing analytes
Scale‑up from analytical or shorter preparative methods
Workflows requiring higher purity separations
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable