Prep HPLC Column, Bidentate C18, 4um, 100A. 30mm ID x 100mm Length. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40018‑P30‑100 Cogent Bidentate C18™ Preparative HPLC Column is a large‑diameter, extended‑length preparative column designed for purification workflows that require both high sample capacity and improved resolving power compared with short 50 mm prep formats. Built on Cogent TYPE‑C™ silica hydride technology, this column provides excellent selectivity, fast equilibration, and very robust column lifetime under demanding preparative conditions.
The stationary phase consists of an aliphatic C18 chain bonded via two direct silicon–carbon bonds (bidentate attachment) to a silica hydride surface. This non‑traditional chemistry creates a phase that is highly hydrophobic yet versatile, supporting strong and stable retention of hydrophobic molecules, metabolites, and amine‑containing analytes. Unlike conventional silica‑based prep C18 materials, the TYPE‑C™ hydride surface remains stable in aqueous‑dominant mobile phases and tolerates low‑pH conditions, expanding method flexibility for purification workflows.
With a 30 mm internal diameter and 100 mm length, this column offers substantially higher plate count than 30 × 50 mm formats, while retaining the high mass‑loading capability required for preparative work. It is ideal when large sample loads contain closely eluting impurities that must be better resolved prior to fraction collection.
System Note: A specialized preparative HPLC system (high‑flow pump capacity, appropriate tubing/valving, injector, and fraction‑collection hardware) is required for columns of this size.
Why Choose the 30 × 100 mm Prep Bidentate C18™ Format
This configuration is commonly selected when:
Large‑scale purification requires both capacity and resolution
30 × 50 mm columns do not adequately resolve target compounds
Hydrophobic or basic analytes challenge traditional prep C18 phases
Higher fraction purity is needed without moving to extremely long columns
The longer length enhances interaction time and selectivity, while TYPE‑C™ silica hydride chemistry maintains fast equilibration and long service life despite aggressive preparative methods.
Key Features
Cogent TYPE‑C™ Silica Hydride Technology
Non‑traditional reversed‑phase chemistry
Faster equilibration than conventional prep C18 columns
Very robust lifetimes for repeated purification cycles
Bidentate C18™ Bonding
Two‑point attachment via direct Si–C bonds
Strong, stable hydrophobic retention
Particularly effective for hydrophobic and amine‑containing analytes
Preparative Geometry with Enhanced Resolution
30 mm ID × 100 mm length
Higher plate count vs. 30 × 50 mm columns
Supports tighter fraction cuts with high mass loading
Broad Operating Window
Compatible with aqueous‑dominant mobile phases
Stable under low‑pH conditions
Tolerates aggressive purification methods
Typical Applications
Preparative purification with high sample loads
Improved separation of closely related compounds
Hydrophobic molecule and metabolite isolation
Amine‑containing analytes
Scale‑up from analytical or smaller preparative formats
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable