Catalog Number - 40031-P30-150

40031-P30-150 Cogent UDA™ (weak cation exchange, WCX) Preparative HPLC Column is built on Cogent TYPE‑C™ silica (silica hydride platform), delivering a uniquely powerful mixed‑mode separation mechanism that combines:

• Reversed phase (hydrophobic interactions)

• Weak cation exchange (active at pH ≥ 6)

• HILIC (polar interaction capability)

The UDA™ ligand (Undecanoic Acid) features an 11‑carbon hydrophobic chain with a terminal carboxylic acid group, enabling selective retention of polar, basic, and ionizable analytes.

This multi‑mode capability offers a significant advantage in large‑scale purification of complex matrices, where traditional preparative C18 or ion exchange columns may not provide sufficient selectivity.

The TYPE‑C silica hydride base delivers important performance advantages:

• Faster equilibration between preparative runs

• Reduced sensitivity to mobile phase moisture

• Extremely robust column lifetimes under repeated use

• Minimal salt required in HILIC mode (cleaner fractions and easier downstream processing)

150 mm Length – Enhanced Resolution for Preparative Workflows

The 150 mm length provides improved resolving power for more challenging separations at scale.

• Higher resolution than 50 mm and 100 mm preparative formats

• Better separation of closely related or co‑eluting compounds

• Increased peak capacity for complex mixtures

✅ Recommended for preparative purification requiring improved resolution and higher purity targets

Flow Rate & System Requirements (30 mm ID, 4 µm)

⚠️ Requires preparative or process‑scale HPLC system capability

• Typical flow rate range: ~25 – 60 mL/min

• Moderate backpressure for 30 mm ID and 150 mm length

• Designed for high‑flow, large‑volume purification workflows

• Compatible with large‑scale fraction collection systems

✅ Important: A specialized preparative or process‑scale HPLC system is required for columns of this size

✅ Best Practice: Use proper sample preparation and a matched guard column to protect the column and maintain long‑term performance

Unique Selectivity – Why Choose UDA™ (WCX)

True Mixed‑Mode Retention

• Hydrophobic (RP)

• Ionic (weak cation exchange)

• Polar (HILIC)

Powerful for Complex Purification

• Resolves co‑eluting and structurally similar compounds

• Highly effective for basic and positively charged analytes

pH‑Controlled Selectivity

• WCX mechanism active at pH ≥ 6

• Retention tunable via pH and ionic strength

✅ Ideal when standard preparative C18 or ion exchange columns cannot achieve sufficient purity

TYPE‑C Silica Advantages

Faster Equilibration

• Improves throughput and reduces downtime

No Strict Moisture Control (HILIC)

• Simplifies solvent preparation

Robust Column Lifetimes

• Designed for repeated large‑scale purification

Low Salt Elution (HILIC Mode)

• Cleaner fractions and improved downstream processing

Cogent UDA™ Column Advantages

Multi‑Mode Flexibility

• RP, HILIC, and WCX in one column

High‑Capacity Prep Scale (30 mm ID)

• Ideal for large‑volume purification and production

Enhanced Resolution (150 mm Length)

• Improved separation performance for difficult mixtures

Typical Applications

• Preparative HPLC purification

• Production‑scale separations

• Complex matrix purification

• Basic and ionizable compound isolation

• Pharmaceutical and research workflows

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Requires preparative or process‑scale HPLC system capability

• Designed for high‑flow operation (30 mm ID columns)

Made‑to‑Order Columns & Pricing Information

This is a custom, made‑to‑order column.

• Columns are manufactured specifically to order

• Orders cannot be canceled once placed

• Custom columns are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification: Class A Custom Item

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.