HPLC Column, Diol, 4um, 4.6mm ID x 100mm Length, 100A. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40060‑10P Diol HPLC Column is manufactured using Cogent TYPE‑C™ silica hydride technology, delivering excellent selectivity, faster equilibration, and robust column lifetime compared to conventional bonded‑silica diol phases. The 4 µm silica hydride particles provide stable chromatographic performance with moderate backpressure, making this column ideal for routine analytical and screening workflows.
The TYPE‑C™ silica hydride surface enables reproducible retention behavior across reversed‑phase (RP), normal‑phase (NP), and HILIC methods, supporting flexible method development without sacrificing robustness or longevity.
Application Focus: Diol Chemistry for Polar Compounds
Diol stationary phases are widely used for the analysis of polar compounds that are difficult to retain using reversed‑phase chromatography. This column is suitable for a broad range of analytes, including:
Polar and non‑polar peptides
Amino acids
Polar metabolites
Small biological and biomolecular compounds
The balanced polarity of the Diol phase allows seamless use across RP, NP, and HILIC modes, making this column a versatile option for multi‑method laboratories.
Cogent TYPE‑C™ Silica Hydride Advantages
Compared to conventional bonded‑silica Diol columns, the TYPE‑C™ silica hydride platform offers important operational benefits:
Faster equilibration, particularly in HILIC separations
Excellent selectivity for polar and mixed‑polarity analytes
Improved robustness and extended column lifetime
Lower susceptibility to silica hydrolysis, enhancing durability
These attributes make the 40060‑10P well suited for high‑reproducibility environments and frequent method cycling.
Why Choose the 4.6 mm × 100 mm Format
The 4.6 mm internal diameter is the analytical standard for routine HPLC, offering high throughput, robust performance, and broad system compatibility. The 100 mm column length provides a balance between resolution and run time, making this format ideal for:
Good resolution of polar analytes
Reliable, repeatable separations
Higher sample loading capacity than narrow‑bore formats
Compatibility with standard HPLC detectors and autosamplers
This configuration is commonly used in QC, method development, and screening applications where ease of use and throughput are priorities.
Particle Size and Performance
The 4 µm particle size delivers a practical balance of efficiency and robustness, providing:
Consistent chromatographic performance
Moderate operating pressures
Broad compatibility with standard HPLC systems
This format is optimized for reliable, routine separations rather than maximum efficiency or low‑flow optimization.
System Requirements and Flow Rates
Typical flow range (4.6 mm ID): ~0.8–1.2 mL/min
System compatibility: Designed for standard analytical HPLC systems
Operational considerations: Flow rates may be adjusted based on mobile‑phase viscosity, temperature, and system pressure limits
No specialized low‑flow hardware is required for this column format.