HPLC Column, Diol, 4um, 4.6mm ID x 150mm Length, 100A. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40060‑15P Diol HPLC Column is manufactured using Cogent TYPE‑C™ silica hydride technology, providing excellent selectivity, faster equilibration, and robust column lifetime compared with conventional bonded‑silica diol columns. The 4 µm silica hydride particles deliver consistent chromatographic performance at moderate backpressure, making this column well suited for extended analytical runs and routine method development.
The TYPE‑C™ silica hydride surface supports stable, reproducible retention behavior across reversed‑phase (RP), normal‑phase (NP), and HILIC modes, allowing flexible use without compromising durability or performance.
Application Focus: Diol Chemistry for Polar Compounds
Diol stationary phases are widely chosen for the separation of polar compounds that are difficult to retain in reversed‑phase chromatography. The 40060‑15P column is effective for a broad range of analytes, including:
Polar and non‑polar peptides
Amino acids
Polar metabolites
Small biological and biomolecular compounds
Its balanced polarity enables reliable operation across RP, NP, and HILIC methods, making it a very popular choice for new method development in analytical laboratories.
Cogent TYPE‑C™ Silica Hydride Advantages
Compared to traditional bonded‑silica Diol columns, the TYPE‑C™ silica hydride platform provides distinct operational advantages:
Faster equilibration, particularly beneficial for HILIC workflows
Excellent selectivity for polar and mixed‑polarity analytes
Improved robustness and extended column lifetime
Reduced susceptibility to silica hydrolysis, supporting long‑term use
These properties make the 40060‑15P well suited for method scouting, optimization, and validation where consistency is critical.
Why Choose the 4.6 mm × 150 mm Format
The 150 mm column length delivers increased resolving power, while the 4.6 mm internal diameter provides higher sample capacity and compatibility with standard analytical HPLC systems. This format is optimized for:
Higher resolution separations of complex polar mixtures
Improved peak capacity during method development
Robust performance in routine analytical and screening workflows
Ease of integration with standard detectors and autosamplers
This configuration is ideal when separation confidence and method robustness are prioritized over minimum run time.
Particle Size and Performance
The 4 µm particle size offers a practical balance of efficiency, durability, and manageable backpressure, providing:
Consistent peak shape and retention
Moderate pressure requirements
Broad compatibility with conventional HPLC systems
This makes the column especially suitable for longer gradients commonly used during new method development.
System Requirements and Flow Rates
Typical flow range (4.6 mm ID): ~0.8–1.2 mL/min
System compatibility: Designed for standard analytical HPLC systems
Operational considerations: Flow rates may be adjusted based on mobile‑phase viscosity, temperature, and system pressure limits
No specialized low‑flow pumping hardware is required for this format.