Prep HPLC Column, RP Phenyl, 10um, 100A. 21.2mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Information:
Cogent RP Phenyl is MICROSOLV's most popular phenyl stationary phase for reversed-phase HPLC and LC-MS applications. Manufactured with high-purity silica and a C3-phenyl bonded phase featuring exhaustive double endcapping, this column provides balanced hydrophobic retention combined with strong π-π interactions. The result is enhanced selectivity for aromatic, heteroaromatic, and moderately polar compounds that may not separate adequately on traditional C18 or C8 columns. Phenyl selectivity is particularly valuable for aromatic APIs, positional isomers, natural products, and structurally related compounds that require separation mechanisms beyond hydrophobic retention alone.
68024-P21-100 is a preparative HPLC column with dimensions of 21.2 mm ID x 100 mm length, packed with 10 µm RP Phenyl particles featuring a 100 Å pore size. The large internal diameter provides substantial sample loading capacity for purification applications, while the 100 mm length offers an excellent balance between throughput and chromatographic efficiency. The C3-phenyl bonded phase provides enhanced selectivity through π-π interactions, making this column highly effective for purification of aromatic analytes, isomers, and compounds containing phenyl ring structures. The 10 µm particle size supports higher flow rates while generating lower backpressure than smaller particle columns. Typical operating flow rates are approximately 15–40 mL/min depending on sample load, mobile phase composition, and system capabilities.
This preparative column is commonly used for purification of positional isomers, tocopherols, flavonoids, polynuclear aromatic compounds, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, and related aromatic compounds. The scalable RP Phenyl chemistry makes it well suited for transferring methods from analytical development to preparative purification. A specialized preparative HPLC system capable of higher flow rates, larger injection volumes, and fraction collection is required. This product is supplied as a Special Order Item manufactured specifically upon receipt of order.
Key Benefits
RP Phenyl stationary phase with C3-phenyl bonded chemistry
Strong π-π interaction selectivity
Fully double endcapped
High-purity silica support
Reduced silanol activity
Reduced peak tailing
Excellent peak symmetry
Ideal for aromatic and phenyl-containing compounds
High sample loading capacity
Scalable from analytical to preparative chromatography
Typical Applications
Preparative HPLC purification
Fraction collection
Positional isomer purification
Aromatic pharmaceutical compounds
Active pharmaceutical ingredient (API) purification
Tocopherol purification
Flavonoid purification
Polynuclear aromatic compound purification
Natural product isolation
Process development and scale-up
Specifications
Product Type: Preparative HPLC Column
Stationary Phase: RP Phenyl
Chromatography Mode: Reversed Phase
Bonded Phase: C3-Phenyl
Endcapping: Fully Double Endcapped
Particle Size: 10 µm
Pore Size: 100 Å
Column Dimensions: 21.2 mm ID x 100 mm
Length: 100 mm
Typical Flow Rate: 15–40 mL/min
Brand: Cogent
Additional Resources
Special Order Item Information
Important Notes
Intended for purification and fraction collection rather than routine analytical HPLC
Often selected when C18 or C8 phases do not provide adequate selectivity
Excellent for aromatic and structurally similar compounds
Strong π-π interactions can improve purification of phenyl-containing analytes
High loading capacity supports preparative-scale isolations
Requires a preparative HPLC system capable of higher flow rates and fraction collection
Special Order Item