Catalog Number - 68024-P21-150

Cogent RP Phenyl is MICROSOLV's most popular phenyl stationary phase for reversed-phase HPLC and LC-MS applications. Built on high-purity silica with a C3-phenyl bonded phase and exhaustive double endcapping, it provides balanced hydrophobic retention combined with strong π-π interactions. This unique selectivity is particularly useful when C18 or C8 columns do not adequately resolve aromatic, heteroaromatic, or structurally related compounds.

68024-P21-150 is a preparative HPLC column packed with 10 µm RP Phenyl particles featuring a 100 Å pore size in a 21.2 mm ID x 150 mm format. The larger internal diameter supports substantial sample loading, while the 150 mm length provides increased resolving power compared to shorter preparative columns. The larger particle size allows operation at higher flow rates with lower backpressure, making the column well suited for purification and scale-up applications. Typical operating flow rates are approximately 15–40 mL/min depending on sample load, mobile phase composition, and system capabilities.

This column is commonly used for purification of positional isomers, aromatic pharmaceuticals, tocopherols, flavonoids, polynuclear aromatic compounds, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, and related aromatic compounds. The scalable RP Phenyl chemistry facilitates method transfer from analytical development to preparative purification workflows.

Key Benefits

• RP Phenyl stationary phase with C3-phenyl bonded chemistry

• Strong π-π interaction selectivity

• High-purity silica support

• Fully double endcapped

• Reduced silanol activity

• Reduced peak tailing

• Excellent peak symmetry

• High preparative loading capacity

• Suitable for aromatic and phenyl-containing compounds

• Scalable from analytical to preparative chromatography

Typical Applications

• Preparative HPLC purification

• Fraction collection

• Positional isomer purification

• Aromatic pharmaceutical purification

• Active pharmaceutical ingredient (API) purification

• Tocopherol purification

• Flavonoid purification

• Polynuclear aromatic compound purification

• Natural product isolation

• Process development and scale-up

Specifications

• Product Type: Preparative HPLC Column

• Stationary Phase: RP Phenyl

• Chromatography Mode: Reversed Phase

• Bonded Phase: C3-Phenyl

• Endcapping: Fully Double Endcapped

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 21.2 mm ID x 150 mm

• Length: 150 mm

• Typical Flow Rate: 15–40 mL/min

• Brand: Cogent

Additional Resources

• View Specifications of Reversed Phase HPLC Columns

• Important Information about Cogent RP Columns

Special Order Item Information

• This product is classified as a Special Order Item.

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• Special Order Items are manufactured or configured specifically for customer requirements and cannot be canceled or returned once an order has been placed.

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Important Notes

• Designed for purification and fraction collection workflows

• Often selected when C18 or C8 phases do not provide adequate selectivity

• Strong π-π interactions can improve separation of aromatic compounds

• Longer column length provides enhanced resolution for purification of closely related compounds

• Requires a preparative HPLC system capable of higher flow rates and fraction collection

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