Process HPLC Column, RP Phenyl, Wide Pore, 10um, 300A. 50mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Information:
Cogent RP Phenyl Wide Pore is MICROSOLV's most popular phenyl stationary phase for reversed-phase HPLC and LC-MS applications involving larger molecules. Built on high-purity silica with a C3-phenyl bonded phase and exhaustive double endcapping, it combines hydrophobic retention with strong π-π interactions to provide enhanced selectivity for aromatic and structurally related compounds that may not separate sufficiently on traditional C18 or C8 columns.
68024-P50-1003M is a process-scale HPLC column packed with 10 µm RP Phenyl Wide Pore particles featuring a 300 Å pore size in a 50 mm ID x 100 mm format. The large internal diameter provides very high sample loading capacity for production-scale purification, while the 100 mm length balances throughput and chromatographic efficiency. The 300 Å pore structure improves accessibility for larger molecules and peptides, while the 10 µm particle size supports high flow rates with lower operating backpressure. Typical operating flow rates are approximately 80–200 mL/min depending on sample load, mobile phase composition, and system capabilities.
This column is particularly effective for purification of larger aromatic compounds, peptides, positional isomers, active pharmaceutical ingredients (APIs), tocopherols, flavonoids, natural products, and related compounds. The RP Phenyl chemistry provides a scalable pathway from analytical method development through preparative purification to process-scale production.
Key Benefits
RP Phenyl Wide Pore stationary phase
C3-phenyl bonded chemistry
Strong π-π interaction selectivity
300 Å pore size for larger molecules and peptides
High-purity silica support
Fully double endcapped
Reduced silanol activity
Reduced peak tailing
Excellent peak symmetry
Scalable from analytical to process chromatography
Typical Applications
Process HPLC purification
Large-scale fraction collection
Peptide purification
Positional isomer purification
Aromatic pharmaceutical purification
Active pharmaceutical ingredient (API) purification
Tocopherol purification
Flavonoid purification
Natural product isolation
Production-scale chromatography
Specifications
Product Type: Process HPLC Column
Stationary Phase: RP Phenyl Wide Pore
Chromatography Mode: Reversed Phase
Bonded Phase: C3-Phenyl
Endcapping: Fully Double Endcapped
Particle Size: 10 µm
Pore Size: 300 Å
Column Dimensions: 50 mm ID x 100 mm
Length: 100 mm
Typical Flow Rate: 80–200 mL/min
Brand: Cogent
Additional Resources
Special Order Item Information
Important Notes
Designed for process-scale purification and production workflows
Often selected when C18 or C8 phases do not provide adequate selectivity
Wide pore design improves accessibility for larger molecules and peptides
Large diameter format supports high sample loading and throughput
Requires a specialized process HPLC system capable of high flow rates and large-volume fraction collection