Syringe Filters, 4mm, RC, 0.45um Pore Size. Brown Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58045-R04-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput micro-volume regenerated cellulose (RC) membrane filters designed for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm regenerated cellulose membrane, these filters deliver low extractables, high analyte recovery, and consistent chromatographic performance, even with very small sample volumes.
Regenerated cellulose membranes offer very low protein binding and minimal hold-up volume, making them ideal for protein solutions, buffers, and cell culture media, especially when maximum recovery is critical.
✅ Critical Compliance Advantage (No Flush Required)
Validated to meet key regulatory standards:
US FDA CFR Title 21, Part 211.92 – minimum fiber release
USP <788> – particulate matter in injectables
USP “Sterile Water for Injection”
Benefits:
✅ No initial flushing required
✅ No 20 µL discard required
✅ Maximizes recovery of micro-volume samples
✅ Reduces risk of failed methods
Performance & Design
The 0.45 µm pore size is optimized for sample clarification and prefiltration, ensuring reliable particulate removal and consistent flow.
The RC membrane provides low adsorption and maximum analyte recovery, making it ideal for biological and aqueous workflows.
The 4 mm format minimizes hold-up volume, making it ideal for micro-volume and high-value samples, while 1000/case packaging supports high-throughput laboratories and production workflows.
Not recommended for use with strong acids or bases.
The brown housing enables quick identification, and each case includes a Certificate of Analysis.
Key Features
0.45 µm Regenerated Cellulose Membrane (Pharma Grade)
Very low protein binding
Ideal for biological and aqueous samples
✅ No Initial Flush Required (Validated)
No 20 µL discard required
Low Hold-Up Volume
Maximizes analyte recovery
Ultra-Low Volume Format (4 mm)
Minimizes hold-up volume
Maximizes recovery
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-volume workflows
Low Extractables
Clean chromatographic results
Biological Compatibility
Suitable for proteins, buffers, and media
Regulatory Compliance
FDA CFR 21 (211.92), USP <788>
Color-Coded (Brown)
Identifies RC filters
Typical Applications
HPLC & UHPLC Sample Preparation – micro-volume filtration
LC‑MS Workflows – high-value sample recovery
Protein & Biomolecule Samples – maximum recovery
Cell Culture Media & Buffers
High-Throughput Laboratories – consistent performance
Specifications
Membrane Material: Regenerated Cellulose (RC)
Pore Size: 0.45 µm
Diameter: 4 mm
Housing: Polypropylene (PP)
Color Code: Brown
Protein Binding: Very Low
Hydrophilicity: Hydrophilic
Extractables: None detectable (no flush required)
Initial Discard Volume: None (20 µL not required)
Chemical Compatibility: Aqueous solutions (avoid strong acids/bases)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21, USP <788>
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options
Purchase regenerated cellulose syringe filters, 0.45 µm, 4 mm – 50/pack quantity
Order regenerated cellulose syringe filters, 0.45 µm, 4 mm – 100/pack quantity