Syringe Filters, 4mm, RC, 0.22um Pore Size. Grey Polypropylene, AQ Brand. 50/PK.
Additional Info:
The 58022-R04-A AQ™ Syringe Filters are pharmaceutical-grade, ultra-low volume regenerated cellulose (RC) membrane filters designed for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm regenerated cellulose membrane, these filters deliver low extractables, high analyte recovery, and consistent chromatographic performance, even with very small sample volumes.
Regenerated cellulose membranes provide very low protein binding and minimal hold-up volume, making them ideal for protein solutions, buffers, and cell culture media, especially when maximum recovery of analytes is critical.
✅ Critical Compliance Advantage (No Flush Required)
Validated to meet key regulatory standards:
US FDA CFR Title 21, Part 211.92 – minimum fiber release
USP <788> – particulate matter in injectables
USP “Sterile Water for Injection”
Benefits:
✅ No initial flushing required
✅ No 20 µL discard required
✅ Maximizes recovery of micro-volume samples
✅ Reduces risk of failed methods
Performance & Design
The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum protection of analytical systems.
The RC membrane ensures low adsorption and excellent recovery, making it ideal for biological and aqueous workflows.
The 4 mm format minimizes hold-up volume, making it ideal for micro-volume and high-value samples, including LC‑MS workflows and method development.
Not recommended for use with strong acids or bases.
The grey housing enables quick identification of 0.22 µm RC filters, and each pack includes a Certificate of Analysis.
Key Features
0.22 µm Regenerated Cellulose Membrane (Pharma Grade)
Very low protein binding
Ideal for biological and aqueous samples
✅ No Initial Flush Required (Validated)
No 20 µL discard required
Low Hold-Up Volume
Maximizes analyte recovery
Sterile Filtration Capability
Removes fine particulates and microorganisms
Ultra-Low Volume Format (4 mm)
Minimizes hold-up volume
Maximizes recovery
Low Extractables
Clean analytical results
Biological Compatibility
Suitable for proteins, buffers, and media
Regulatory Compliance
FDA CFR 21 (211.92), USP <788>
Color-Coded (Grey)
Identifies 0.22 µm RC filters
Typical Applications
HPLC & UHPLC Sample Preparation – micro-volume sterile filtration
LC‑MS Workflows – high-value sample recovery
Protein & Biomolecule Samples – maximum recovery
Cell Culture Media & Buffers
Method Development – limited sample volumes
Specifications
Membrane Material: Regenerated Cellulose (RC)
Pore Size: 0.22 µm
Diameter: 4 mm
Housing: Polypropylene (PP)
Color Code: Grey
Protein Binding: Very Low
Hydrophilicity: Hydrophilic
Extractables: None detectable (no flush required)
Initial Discard Volume: None (20 µL not required)
Chemical Compatibility: Aqueous solutions (avoid strong acids/bases)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21, USP <788>
Pack Size: 50/PK
Brand: AQ™
Resources & Ordering Options
Purchase regenerated cellulose syringe filters, 0.22 µm, 4 mm – 100/pack quantity
Order regenerated cellulose syringe filters, 0.22 µm, 4 mm – 1000/case quantity