Catalog Number - 58022-P25-C

The 58022-P25-C AQ™ Syringe Filters are pharmaceutical-grade, high-performance membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm PTFE (Polytetrafluoroethylene) membrane, these filters deliver exceptional chemical resistance, sterile filtration capability, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results.

PTFE membranes are the preferred solution for organic solvent systems, providing superior resistance to aggressive solvents, acids, and bases, making them ideal for demanding analytical and chemical workflows.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 211.92 for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 200 µL of filtrate

• ✅ Preserves valuable samples

• ✅ Eliminates a common source of failed methods and investigations

👉 This provides a significant operational and compliance advantage for QC/QA laboratories, especially when performing sterile filtration with costly or regulated solvent systems.

Performance & Design

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical systems.

PTFE membrane chemistry offers maximum chemical durability and compatibility, ensuring stable performance in organic solvents, strong acids, and alkaline environments, without degradation.

⚠️ Important: PTFE membranes are hydrophobic and not recommended for 100% aqueous or buffer solutions, making them best suited for organic or mixed solvent systems requiring sterile filtration.

The advanced 16-channel outlet design minimizes back pressure, allowing smooth filtration with reduced hand force, improving ergonomics and consistency in high-throughput workflows.

The 25 mm format supports higher sample volumes and routine high-throughput filtration, while the blue housing enables quick identification of 0.22 µm PTFE filters.

Each pack includes a Certificate of Analysis, ensuring full traceability and regulatory compliance.

Key Features

0.22 µm PTFE Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Excellent chemical resistance

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• No 200 µL discard required

Superior Chemical Resistance

• Compatible with strong solvents, acids, and bases

• Will not degrade in harsh conditions

⚠️ Hydrophobic Membrane

• Not suitable for 100% aqueous solutions

• Designed for organic or mixed-phase systems

Sterile Filtration Capability

• Suitable for critical pharmaceutical and analytical workflows

High Throughput Performance (25 mm)

• Handles larger volumes

• Ideal for routine laboratory use

Advanced 16-Channel Outlet Design

• Reduces back pressure

• Requires less hand force

Low Extractables

• Clean chromatographic baselines

• Improves reproducibility

Regulatory Compliance

• Meets FDA CFR 21 (211.92) requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

Color-Coded (Blue)

• Identifies 0.22 µm PTFE filters

Typical Applications

• HPLC & UHPLC Sample Preparation – sterile filtration of organic solvents

• Pharmaceutical Analysis – dissolution and QC workflows

• Organic & Chemical Analysis – aggressive solvent systems

• Environmental Testing – non-aqueous sample filtration

• Industrial Laboratories – strong solvent applications

• Regulated Laboratory Methods – validated, compliant processes

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: PTFE (Polytetrafluoroethylene)

• Pore Size: 0.22 µm

• Diameter: 25 mm

• Housing Material: Polypropylene (PP)

• Color Code: Blue (0.22 µm PTFE)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Organic solvents, acids, bases

• Hydrophilicity: Hydrophobic (not for aqueous solutions)

• Extractables: None detectable (no flush required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21 (211.92), USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 100/PK

• Brand: AQ™

Resources & Ordering Options

• Order PTFE syringe filters, 0.22 µm, 25 mm – 1000/case quantity

• Purchase PTFE syringe filters, 0.22 µm, 25 mm – 50/pack quantity