Syringe Filters, 25mm, PTFE, 0.22um Pore Size. Blue Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58022-P25-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm PTFE (Polytetrafluoroethylene) membrane, these filters provide exceptional chemical resistance, sterile filtration capability, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results in high-volume workflows.
PTFE membranes are the preferred choice for organic solvent systems, offering superior durability and compatibility with aggressive chemicals, including strong solvents, acids, and bases, making them ideal for demanding analytical and industrial workflows.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 211.92 for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 200 µL of filtrate
✅ Preserves valuable samples
✅ Eliminates a common source of failed methods and costly investigations
👉 This delivers a major operational and compliance advantage for QC/QA laboratories, especially in regulated, high-throughput environments using organic solvent systems.
Performance & Design
The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical instrumentation.
PTFE membrane chemistry provides maximum chemical compatibility and durability, ensuring reliable performance in organic solvents, strong acids, and alkaline solutions, without degradation over time.
⚠️ Important: PTFE membranes are hydrophobic and not recommended for 100% aqueous or buffer solutions, making them best suited for organic or mixed solvent systems requiring sterile filtration.
The advanced 16-channel outlet design minimizes back pressure, enabling smooth filtration with reduced hand force, improving ergonomics and consistency in repetitive workflows.
The 25 mm format supports larger sample volumes and high-throughput applications, while the bulk 1000/case packaging is ideal for QC labs and production-scale environments.
The blue housing allows quick identification of 0.22 µm PTFE filters, and each case includes a Certificate of Analysis for full traceability and compliance.
Key Features
0.22 µm PTFE Membrane (Pharma Grade)
Ideal for sterile filtration and fine particulate removal
Excellent chemical resistance
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 200 µL discard required
Superior Chemical Resistance
Compatible with strong solvents, acids, and bases
Will not degrade under harsh conditions
⚠️ Hydrophobic Membrane
Not suitable for 100% aqueous solutions
Designed for organic or mixed-phase systems
Sterile Filtration Capability
Suitable for critical analytical and pharmaceutical workflows
High Throughput Performance (25 mm)
Handles larger volumes
Ideal for routine and high-volume applications
Advanced 16-Channel Outlet Design
Reduces back pressure
Requires less hand force
Low Extractables
Ensures clean chromatographic baselines
Improves reproducibility
Regulatory Compliance
Meets FDA CFR 21 (211.92) requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Color-Coded (Blue)
Identifies 0.22 µm PTFE filters
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-throughput QC environments
Typical Applications
HPLC & UHPLC Sample Preparation – sterile filtration of organic solvents
Pharmaceutical Analysis – dissolution and QC workflows
Organic & Chemical Analysis – aggressive solvent systems
Environmental Testing – non-aqueous sample filtration
Industrial Laboratories – harsh solvent applications
High-Throughput Labs – consistent and efficient performance
Specifications
Filter Type: Syringe Filter (Pharma Grade)
Membrane Material: PTFE (Polytetrafluoroethylene)
Pore Size: 0.22 µm
Diameter: 25 mm
Housing Material: Polypropylene (PP)
Color Code: Blue (0.22 µm PTFE)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Organic solvents, acids, bases
Hydrophilicity: Hydrophobic (not for aqueous solutions)
Extractables: None detectable (no flush required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21 (211.92), USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options
Order PTFE syringe filters, 0.22 µm, 25 mm – 100/pack quantity
Purchase PTFE syringe filters, 0.22 µm, 25 mm – 50/pack quantity