Catalog Number - 58022-P25-A

The 58022-P25-A AQ™ Syringe Filters are pharmaceutical-grade, high-performance membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm PTFE (Polytetrafluoroethylene) membrane, these filters deliver exceptional chemical resistance, sterile filtration capability, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results.

PTFE membranes are the preferred choice for organic solvent systems, offering superior resistance to strong solvents, acids, and bases, making them ideal for demanding analytical and chemical applications.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 211.92 for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 200 µL of filtrate

• ✅ Preserves valuable samples

• ✅ Eliminates a common source of failed methods and investigations

👉 This provides a major operational and compliance advantage for QC/QA laboratories, especially in regulated environments requiring sterile filtration with organic solvents.

Performance & Design

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical instruments.

PTFE membrane chemistry provides maximum chemical compatibility and durability, making it ideal for organic solvent-based workflows and aggressive chemical conditions where other membrane types may degrade.

⚠️ Important: PTFE is hydrophobic and not recommended for 100% aqueous or buffer solutions, making it best suited for organic or mixed solvent systems requiring sterile filtration.

The advanced 16-channel outlet design reduces back pressure, allowing smooth filtration with reduced hand force, improving ergonomics and consistency in high-throughput workflows.

The 25 mm format supports higher sample volumes and high-throughput applications, while the blue housing allows quick identification of 0.22 µm PTFE filters.

Each pack includes a Certificate of Analysis for full traceability and compliance.

Key Features

0.22 µm PTFE Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Excellent chemical resistance

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• No 200 µL discard required

Superior Chemical Resistance

• Compatible with strong solvents, acids, and bases

• Will not degrade under harsh conditions

⚠️ Hydrophobic Membrane

• Not suitable for 100% aqueous solutions

• Ideal for organic or mixed-phase workflows

Sterile Filtration Capability

• Suitable for critical analytical and pharmaceutical workflows

High Throughput Performance (25 mm)

• Handles larger sample volumes

• Ideal for routine and high-volume applications

Advanced 16-Channel Outlet Design

• Reduces back pressure

• Requires less hand force

Low Extractables

• Clean chromatographic baselines

• Improved reproducibility

Regulatory Compliance

• Meets FDA CFR 21 (211.92) requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

Color-Coded (Blue)

• Identifies 0.22 µm PTFE filters

Typical Applications

• HPLC & UHPLC Sample Preparation – sterile filtration of organic solvents

• Pharmaceutical Analysis – dissolution and QC testing

• Organic Chemistry Applications – aggressive solvent filtration

• Environmental Testing – non-aqueous samples

• Industrial & Chemical Labs – harsh solvent systems

• Regulated Laboratory Methods – validated and compliant processes

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: PTFE (Polytetrafluoroethylene)

• Pore Size: 0.22 µm

• Diameter: 25 mm

• Housing Material: Polypropylene (PP)

• Color Code: Blue (0.22 µm PTFE)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Organic solvents, acids, bases

• Hydrophilicity: Hydrophobic (not for aqueous solutions)

• Extractables: None detectable (no flush required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21 (211.92), USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 50/PK

• Brand: AQ™

Resources & Ordering Options

• Purchase PTFE syringe filters, 0.22 µm, 25 mm – 100/pack quantity

• Order PTFE syringe filters, 0.22 µm, 25 mm – 1000/case quantity