USP® L11 Methods | 1.9, 3 or 5um Particle Sizes | Alternate Selectivity
The Cogent Biphenyl Phase provides Reversed Phase chromatographic interactions that are more polar, have greater shape selectivity and employ strong pi-pi interactions relative to alkyl phases. They are used in either 2-dimensional chromatography or as an alternate selectivity phase.
These columns contain a biphenyl group that imparts alternate selectivity when compared to a standard C18. The retention window matches standard C18 columns which is very helpful when exchanging columns during method development as the mobile phase conditions can remain the same. This will provide an alternate selectivity for many compounds of interest with little or no change to the method.
Used for: Aromatic (pi-pi) compounds, analytes with electron withdrawing groups (halogens, nitro groups, ketones, esters and acids), benzodiazepines, drugs of abuse, moderately polar analytes (alkenes, ketones, nitriles, etc.), steroids and most analytes that contain aromatic moieties, substituted aromatics and functional groups such as phenols.
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Alternate selectivity to alkyl phases
Fast separations with excellent resolution and sensitivity
Mixed-mode selectivity for aromatic and moderately polar analytes
Enhanced π-π interactions with aromatics v. phenyl phases
Hydrophobic Interaction, pi-pi, Dipole-Dipole, H-bonding and Shape Selectivities all in one column.
Compatibility with 98% aqueous conditions
Excellent lot-to-lot reproducibility
Great column lifetime