RSA‑Pro X™ surface‑treated vials and inserts are designed to minimize analyte adsorption and improve recovery when working with proteins, peptides, enzymes, and other bioactive or glass‑sensitive compounds. This subcategory includes surface‑treated autosampler vials and low‑volume inserts used in bioanalytical, pharmaceutical, and LC‑MS workflows where sample integrity is critical.
Unmodified borosilicate glass contains surface hydroxyl groups (silanols) and siloxane structures that can interact with analytes, particularly in aqueous environments. These surface features, along with naturally occurring metal ions within the glass matrix, can contribute to non‑specific adsorption, leading to sample loss and reduced reproducibility—especially for basic, polar, or higher‑molecular‑weight compounds.
RSA‑Pro X™ technology builds upon RSA™ reduced‑surface‑activity glass by applying a complete, hydrolytically stable surface treatment that remains intact even in 100 % aqueous conditions. The resulting surface is hydrophobic and chemically resistant, reducing interactions between samples and the vial or insert wall and helping preserve analyte concentration over time.
RSA‑Pro X™ vials and inserts are commonly selected for applications such as:
Bioanalytical method development
Stability and storage studies
Reference standards and QC testing
Dissolution testing and sample shipping
These products are designed for workflows where low adsorption, long‑term stability, and reproducible recovery are essential.
RSA‑Pro X™ inserts are offered within the U‑2D™ Micro‑Sample Management System, supporting racked handling, low‑volume analysis, and high‑throughput laboratory workflows. Selection of RSA‑Pro X™ products should consider sample chemistry, solvent composition, and analytical sensitivity requirements.
Additional resources:
