Date: 12-OCTOBER-2021 Last Updated: 24-AUGUST-2026
Oral Anti-Viral Medication - HILICMolnupiravir can be analyzed using this simple "inverse gradient" HPLC Method shown below. This is offered as an orthogonal approach for a Reversed Phased Method and will show various polar impurities not detected by Reversed Phase HPLC.
Peak:
Molnupiravir
Method Conditions:
Column: Cogent Diamond Hydride™, 4 µm, 100 Å
Dimensions: 4.6 x 75 mm
Mobile Phase: (95:5) Acetonitrile / DI Water with 0.1% Formic Acid
Injection Volume: 1 µL
Flow Rate: 1.0 mL / minute
Detection: UV @ 254 nm
Sample Preparation:
Molnupiravir is dissolved at a concentration of 0.5
mg / mL in (50:50) DI Water / Acetonitrile
Note : Molnupiravir is an oral antiviral drug that was developed for the treatment of influenza. It is a prodrug of the synthetic nucleoside derivative N4-hydroxycytidine, and exerts its antiviral action through introduction of copying errors during viral RNA replication.
