Membrane discs are used for preparation and filtration of HPLC and LC‑MS mobile phases, helping remove particulates while minimizing chemical extractables and background contamination. This category includes pre‑cut membrane filter discs designed for use with vacuum solvent filtration and degassing assemblies in analytical laboratories.
Proper membrane selection is critical for maintaining solvent purity, protecting chromatographic systems, and supporting reproducible analytical performance—particularly in LC‑MS and UHPLC applications, where background contamination can significantly affect results.
Membrane Materials & Performance
Membrane discs in this category are manufactured from high‑purity polymer materials selected for:
Ultra‑low extractables and leachables
Broad chemical compatibility
Consistent pore structure and flow characteristics
These membranes are suitable for use in both aqueous and organic mobile‑phase systems and are commonly selected for solvent‑level filtration prior to system introduction.
Compatibility & Formats
Pre‑cut membrane discs are available in standard diameters, including:
25 mm
47 mm
Additional sizes such as 13 mm and 90 mm, depending on configuration
These formats are compatible with vacuum solvent filter degassers and glass filtration assemblies commonly used for mobile‑phase preparation.
Membrane Type Options
Available membrane materials include:
Hydrophilic or hydrophobic PTFE
Nylon
Mixed cellulose ester (MCE)
Cellulose acetate
PES
PVDF
Polypropylene
Membrane selection should be based on solvent composition, wetting characteristics, chemical compatibility, and analytical sensitivity.
Pore Size Guidance
For most high‑performance liquid chromatography applications:
0.22 µm membranes are recommended for UHPLC and reversed‑phase mobile phases
Larger pore sizes may be used for preliminary filtration or less demanding workflows
Applications & Use Cases
Membrane discs in this category are commonly used for:
HPLC, UHPLC, and LC‑MS mobile‑phase preparation
Solvent filtration prior to degassing
Removal of particulate contamination before system introduction
Analytical and regulated laboratory workflows requiring low background signal
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