What is the Difference Between a Luer Lock and a Luer Slip Connector or Syringe - FAQ
September 27, 2012
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Date: 27-SEPTEMBER-2012   Last Updated: 3-NOVEMBER-2025

When working with syringes and accessories like syringe filters and tubing connectors, it's important to understand the difference between Luer Lock and Luer Slip connectors, as each serves a distinct purpose in laboratory and clinical settings.

Luer Slip Connector

  • A Luer Slip connection allows the syringe or device to simply slide onto the tip of another compatible component (e.g., a syringe filter).
  • To ensure a snug fit, apply firm forward pressure and give the device a quarter turn during attachment.
  • While this connection is generally secure for most applications, it does not lock in place and may disconnect under high pressure or vigorous handling.

Luer Lock Connector

  • A Luer Lock connection features a threaded locking mechanism that securely fastens the device to the syringe.
  • The “wings” or threads on the syringe filter screw into the syringe’s Luer Lock fitting, creating a fixed, leak-resistant seal.
  • This design is ideal for applications involving high back pressure or where a secure, stable connection is critical for safety and performance.

Key Differences at a Glance

Feature Luer Slip Luer Lock
Connection Type Push-on with optional twist Screw-on with locking parts
Security Moderate High
Best For General use High-pressure or critical systems
Risk of Disconnection Possible under pressure Minimal

More Information Chrom Syringes

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