Cogent TYPE-C™ HPLC columns are engineered with a unique bonded silica surface that offers significant performance advantages in both method development and routine analysis. Here's how they enable faster, more efficient workflows:
1. Rapid Equilibration
Thanks to the distinctive surface chemistry of TYPE-C™ silica, these columns equilibrate in just 3–5 column volumes after gradient runs. In contrast, conventional silica-based columns often require 25–40 column volumes to reach comparable stability and precision. This dramatically reduces downtime between runs.
2. Higher Flow Rates with Lower Viscosity
Aqueous Normal Phase (ANP) methods used with TYPE-C™ columns typically employ high concentrations of acetonitrile. This reduces mobile phase viscosity by 50–60% compared to water-based systems, allowing flow rates to be increased by 2–3× without compromising peak shape or generating excessive back pressure.
3. Smaller Particle Sizes for Higher Efficiency
Cogent TYPE-C™ columns are available in 4 µm and 2.2 µm particle sizes, delivering near-UHPLC performance without the extreme back pressures associated with sub-2 µm particles. This enables high-resolution separations on standard HPLC systems.
Here is the visual comparison chart summarizing the performance advantages of Cogent TYPE-C™ HPLC columns versus conventional silica-based columns:
Bottom Line:
Faster equilibration, higher flow rates, and high-efficiency particles mean
more runs, more data, and faster insights
—without sacrificing reproducibility or resolution.
