Why doesn't triphenylamine a tertiary amine retain in Aqueous Normal Phase ANP - FAQ
There can be many reasons why any compound may not retain in any given HPLC Method, however in this case, triphenylamine has three bulky phenyl groups
(see structure below)
, which can create steric hindrance from interaction with the stationary phase due to the tertiary amine.
NOTE: Tertiary amines are the least polar amine and will have less retention than primary or secondary amines in Aqueous Normal Phase ANP HPLC methods.
NOTE: Tertiary amines are the least polar amine and will have less retention than primary or secondary amines in Aqueous Normal Phase ANP HPLC methods.
Triphenylamine